2. GPCR/G Protein Neuronal Signaling
  3. GPR139
  4. Zelatriazin

Zelatriazin  (Synonyms: TAK-041; NBI-1065846)

Cat. No.: HY-132228 Purity: 99.89%
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Zelatriazin (TAK-041; NBI-1065846) is a potent and selective GPR139 agonist with an EC50 of 22 nM. Zelatriazin has the potential for the research of negative symptoms associated with schizophrenia.

For research use only. We do not sell to patients.

Zelatriazin Chemical Structure

Zelatriazin Chemical Structure

CAS No. : 1929519-13-0

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 198 In-stock
Solution
10 mM * 1 mL in DMSO USD 198 In-stock
Solid
5 mg USD 180 In-stock
10 mg USD 288 In-stock
25 mg USD 576 In-stock
50 mg USD 921 In-stock
100 mg USD 1470 In-stock
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Based on 1 publication(s) in Google Scholar

Zelatriazin Related Antibodies

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Description

Zelatriazin (TAK-041; NBI-1065846) is a potent and selective GPR139 agonist with an EC50 of 22 nM. Zelatriazin has the potential for the research of negative symptoms associated with schizophrenia[1].

In Vivo

Zelatriazin (0.03-3 mg/kg; P.o.) improves social behavior in BALB/c mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[1]
Dosage: 0.03, 0.3, and 3 mg/kg
Administration: P.o.
Result: Dose-dependently improved the social behavior of BALB/c mice.
Clinical Trial
Molecular Weight

392.33

Formula

C18H15F3N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C1=CC=C(OC(F)(F)F)C=C1)C)CN2N=NC3=CC=CC=C3C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5489 mL 12.7444 mL 25.4887 mL
5 mM 0.5098 mL 2.5489 mL 5.0977 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.37 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5489 mL 12.7444 mL 25.4887 mL 63.7219 mL
5 mM 0.5098 mL 2.5489 mL 5.0977 mL 12.7444 mL
10 mM 0.2549 mL 1.2744 mL 2.5489 mL 6.3722 mL
15 mM 0.1699 mL 0.8496 mL 1.6992 mL 4.2481 mL
20 mM 0.1274 mL 0.6372 mL 1.2744 mL 3.1861 mL
25 mM 0.1020 mL 0.5098 mL 1.0195 mL 2.5489 mL
30 mM 0.0850 mL 0.4248 mL 0.8496 mL 2.1241 mL
40 mM 0.0637 mL 0.3186 mL 0.6372 mL 1.5930 mL
50 mM 0.0510 mL 0.2549 mL 0.5098 mL 1.2744 mL
60 mM 0.0425 mL 0.2124 mL 0.4248 mL 1.0620 mL
80 mM 0.0319 mL 0.1593 mL 0.3186 mL 0.7965 mL
100 mM 0.0255 mL 0.1274 mL 0.2549 mL 0.6372 mL
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Zelatriazin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zelatriazin1929519-13-0TAK-041 NBI-1065846TAK041TAK 041NBI1065846NBI 1065846NBI-1065846GPR139G Protein-Coupled Receptor 139socialinteractiondeficitsBALB/cmousenegativesymptomsschizophreniaInhibitorinhibitorinhibit

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