2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glucokinase
  5. Glucokinase Activator

Glucokinase Activator

Glucokinase Activators (29):

Cat. No. Product Name Effect Purity
  • HY-133127A
    AR453588 hydrochloride
    		Activator
    AR453588 hydrochloride is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 hydrochloride shows anti-hyperglycemic activity.
  • HY-101788
    Glucokinase activator 1
    		Activator
    Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM.
  • HY-116946
    Glucokinase activator 6
    		Activator
    Glucokinase activator 6 (compound 9) is a potent glucokinase activator, with an EC50 of 0.09 μM. Glucokinase activator 6 can be used for type 2 diabetes (T2D) research.
  • HY-121070
    AZD1092
    		Activator
    AZD1092 is an orally active glucokinase (GK) activator with an EC50 value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D).
  • HY-14747
    Piragliatin
    		Activator
    Piragliatin (RO4389620) is an activator for glucokinase, which reduces endogenous glucose production, increases β-cell function and glucose utilization, and thus decreases the blood glucose levels. Piragliatin exhibits antidiabetic efficacy.
  • HY-109030R
    Dorzagliatin (Standard)
    		Activator
    Dorzagliatin (Standard) is the analytical standard of Dorzagliatin. This product is intended for research and analytical applications. Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
  • HY-116682
    GKA-71
    		Activator
    GKA-71 is an orally active Glucokinase activator, possesses an islet protective effect.
  • HY-156923
    Glucokinase activator 5
    		Activator
    Glucokinase activator 5 (compound 6) is a glucokinase activator.
  • HY-U00411
    PSN-GK1
    		Activator
    PSN-GK1 is a potent glucokinase activator with an EC50 of 0.13 μM.