2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glucokinase
  5. Glucokinase Modulator

Glucokinase Modulator

Glucokinase Modulators (2):

Cat. No. Product Name Effect Purity
  • HY-12411
    AMG-3969
    		Modulator 99.62%
    AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM.
  • HY-12614
    AMG-1694
    		Modulator
    AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals.