2. Signaling Pathways
  3. Anti-infection
  4. HBV

HBV

Hepatitis B virus

HBV

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HBV (Hepatitis B virus), abbreviated HBV, is a species of the genus Orthohepadnavirus, which is likewise a part of the Hepadnaviridae family of viruses. HBV causes the disease hepatitis B. The hepatitis B virus is classified as the type species of the Orthohepadnavirus, which contains three other species: the Ground squirrel hepatitis virus, Woodchuck hepatitis virus, and theWoolly monkey hepatitis B virus. The genus is classified as part of the Hepadnaviridae family. HBV is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes present on its envelope proteins, and into eight genotypes (A–H) according to overall nucleotide sequence variation of the genome. The genotypes have a distinct geographical distribution and are used in tracing the evolution and transmission of the virus. Differences between genotypes affect the disease severity, course and likelihood of complications, and response to treatment and possibly vaccination.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N8294
    Kadsulignan L
    		Inhibitor
    Kadsulignan L is a Lignans product that can be isolated from the stems of Kadsura japonica.
    Kadsulignan L
  • HY-N3094
    Periglaucine A
    		Inhibitor
    Periglaucine A, a hasubanane-type alkaloid, can be isolated from Pericampylus glaucus. Periglaucine A can inhibits HBV surface antigen (HBsAg) secretion in Hep G2.2.15 cells. Periglaucine A also shows anti-HIV-1 activity in C8166 cells (EC50: 204 μM).
    Periglaucine A
  • HY-119702
    YZ51
    YZ51 is a derivative of Osalmid (HY-B2116) with stronger ribonucleotide reductase (RR) inhibitory activity and HBV replication inhibition ability than Osalmid. The IC50 of YZ51 against recombinant RR activity is 0.6 μM, and the IC50 against HepG2.2.15 cell RR activity is 23.7 μM.
    YZ51
  • HY-N15262
    Schinlignan B
    		Inhibitor
    Schinlignan B (Angeloylgomisin P) is a lignan with antioxidant, anti-HIV, anti-HBV activities, which is found in plants of the Schisandra genus. Schinlignan B is promising for research of antioxidant-associated diseases.
    Schinlignan B
  • HY-B0035B
    Sulfamethazine 100 µg/mL in acetonitrile
    		Inhibitor
    Sulfamethazine 100 μg/mL in acetonitrile (Sulfadimidine 100 μg/mL in acetonitrile) is an antimicrobial agent that induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex-dependent pharmacokinetics and is metabolized by CYP2C11 in males.
    Sulfamethazine 100 µg/mL in acetonitrile
  • HY-N0063R
    Punicalagin (Standard)
    		Inhibitor
    Punicalagin (Standard) is the analytical standard of Punicalagin. This product is intended for research and analytical applications. Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19.
    Punicalagin (Standard)
  • HY-N15419
    Acutumidine
    		Inhibitor
    Acutumidine (compound 4) is an alkaloid with anti-HBV activity that can be isolated from Hypserpa nitida Miers. Acutumidine inhibits the production of HBsAg in Hep G2.2.15 cells stably transfected with HBV genome with an IC50 value of 2.023 mM.
    Acutumidine
  • HY-171181
    ZINC20451377
    		Inhibitor
    ZINC20451377 is a small molecule targeting hepatitis B (HBV) surface antigen (HBsAg) and can effectively inhibit wild-type hepatitis B and tenofovir (HY-13910)-resistant hepatitis B.
    ZINC20451377
  • HY-B0017R
    Telbivudine (Standard)
    		Inhibitor
    Telbivudine (Standard) is the analytical standard of Telbivudine. This product is intended for research and analytical applications. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication.
    Telbivudine (Standard)
  • HY-108917A
    Morphothiadin mesylate
    		Inhibitor
    Morphothiadin (GLS4) mesylate is a potent inhibitor of wild-type and Adefovir (HY-B1826)-resistant HBV replication with an IC50 value of 12 nM.
    Morphothiadin mesylate
  • HY-169125
    HBV-IN-49
    		Inhibitor
    HBV-IN-49 is an anti-hepatitis B virus (HBV) agent that inhibits HBV replication. HBV-IN-49 can be utilized in infection research.
    HBV-IN-49
  • HY-N12483
    Catenulopyrizomicin A
    		Inhibitor
    Catenulopyrizomicin A has a thiazolyl pyridine moiety. Catenulopyrizomicin A can be isolated from the fermentation broth of rare actinomycete Catenuloplanes sp. Catenulopyrizomicin A has anti-Hepatitis B virus activity.
    Catenulopyrizomicin A
  • HY-14844
    Lagociclovir
    		Inhibitor
    Lagociclovir (FLG) is a nucleoside analogue that inhibits wild-type hepatitis B virus (HBV) replication in a human hepatoma cell line permanently expressing HBV.
    Lagociclovir
  • HY-B0150S3
    Nicotinamide-d3
    		Inhibitor
    Nicotinamide-d3 (Niacinamide-d3) is deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity.
    Nicotinamide-d<sub>3</sub>
  • HY-N3609
    Coclauril
    		Inhibitor
    Coclauril is an inhibitor of HBV. Coclauril inhibits HBV replication in the human hepatoblastoma cell line with an EC50 of 7.6 μg/mL.
    Coclauril
  • HY-17426S1
    Famciclovir-d6
    		Inhibitor
    Famciclovir-d6 (BRL 42810-d6) is deuterium labeled Famciclovir. Famciclovir (BRL 42810) is an orally active nucleoside analogue. Famciclovir is an antiviral agent with potent activities against HBV, HSV and VZV. Famciclovir can be used for the research of herpesvirus infection.
    Famciclovir-d<sub>6</sub>
  • HY-N0058R
    4,5-Dicaffeoylquinic acid (Standard)
    		Inhibitor
    4,5-Dicaffeoylquinic acid (Standard) is the analytical standard of 4,5-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects.
    4,5-Dicaffeoylquinic acid (Standard)
  • HY-117999
    BAY39-5493
    		Inhibitor
    BAY39-5493 is a non-nucleoside inhibitor that inhibits HBV replication. BAY39-5493 inhibits viral DNA replication by preventing the formation of viral core particles (nucleocapsids). The IC50 value of BAY39-5493 against HBV in stably transfected HepG2.2.15 cells is 0.03 μM.
    BAY39-5493
  • HY-17426R
    Famciclovir (Standard)
    		Inhibitor
    Famciclovir (Standard) is the analytical standard of Famciclovir. This product is intended for research and analytical applications. Famciclovir (BRL 42810) is an orally active nucleoside analogue. Famciclovir is an antiviral agent with potent activities against HBV, HSV and VZV. Famciclovir can be used for the research of herpesvirus infection.
    Famciclovir (Standard)
  • HY-116607
    BAY38-7690
    		Inhibitor
    BAY38-7690 is a non-nucleoside inhibitor that inhibits HBV replication. BAY38-7690 inhibits viral DNA replication by preventing the formation of viral core particles (nucleocapsids). The IC50 value of BAY38-7690 against HBV in stably transfected HepG2.2.15 cells is 0.15 μM.
    BAY38-7690
Cat. No. Product Name / Synonyms Application Reactivity