2. Signaling Pathways
  3. Epigenetics
  4. Histone Methyltransferase
  5. EHMT2/G9a/KMT1C Isoform
  6. EHMT2/G9a/KMT1C Inhibitor

EHMT2/G9a/KMT1C Inhibitor

EHMT2/G9a/KMT1C Inhibitors (22):

Cat. No. Product Name Effect Purity
  • HY-155020
    Antitumor agent-101
    		Inhibitor
    Antitumor agent-101 is a selective covalent inhibitor of lysine methyltransferases G9a/GLP, with IC50s of 8.5 nM and 5.5 nM for G9a and GLP, respectively. Antitumor agent-101 shows antitumor efficacy in the PANC-1 xenograft model.
  • HY-116971
    DCG066
    		Inhibitor
    DCG066 is an inhibitor of lysine methyltransferase G9a. DCG066 can bind directly to G9a and inhibit methyltransferase activity in vitro. DCG066 decreases di-methylation levels of histone H3 lysine 9 (H3K9Me2), inhibits cell proliferation and induces cell apoptosis. DCG066 displays low cytotoxicity in leukemia cell lines with high levels of G9a expression, including K562.