CSV0C018875

Cat. No.: HY-133031: FAQs
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CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor. CSV0C018875 exhibits lesser cytotoxicity than BIX-01294.

For research use only. We do not sell to patients.

CSV0C018875 Chemical Structure

CAS No. : 442150-41-6

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Other Forms of CSV0C018875:

CSV0C018875 hydrochloride Get quote

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•Related Small Molecules:

•Related Proteins:

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
Purity & Documentation
References
Customer Review

Description

CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor. CSV0C018875 exhibits lesser cytotoxicity than BIX-01294^[1].

IC₅₀ & Target^[1]

G9a

In Vitro

CSV0C018875 (2.5-20 μM; 48 hours) inhibits the levels of H3K9me2 modifications in the histones^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	HEK293 cells
Concentration:	2.5 μM, 10 μM, 20 μM
Incubation Time:	48 hours
Result:	Inhibited the enzymatic activity of G9a in a dose-dependent manner in HEK293 cells.

Molecular Weight

312.79

Formula

C₁₈H₁₇ClN₂O

CAS No.

442150-41-6

SMILES

ClC(C=C1)=CC2=C1N=C(C)C=C2NC3=CC=C(OCC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. M Ramya Chandar Charles, et al. Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening. Biochimie. 2020 Jan;168:220-230. [Content Brief]

CSV0C018875 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CSV0C018875442150-41-6Histone MethyltransferaseG9aEHMT2lessercytotoxicityInhibitorinhibitorinhibit

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