2. Signaling Pathways
  3. MAPK/ERK Pathway
  4. MEK
  5. MEK Antagonist

MEK Antagonist

MEK Isoform Comparison

MEK Antagonists (2):

Cat. No. Product Name Effect Purity
  • HY-100627
    APS-2-79
    		Antagonist 99.38%
    APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling.
  • HY-100627A
    APS-2-79 hydrochloride
    		Antagonist
    APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling.