2. Signaling Pathways
  3. MAPK/ERK Pathway
  4. MNK

MNK

Mitogen activated protein kinase interacting kinase; MAP kinase interacting kinase; MAPK interacting kinase

MNK

Related Products

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Mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1 and MNK2) phosphorylate the oncogene eIF4E on serine 209. This phosphorylation has been reported to be required for its oncogenic activity. Eukaryotic initiation factor 4E (eIF4E) is a key component of the translational machinery and an important modulator of cell growth and proliferation. The activity of eIF4E is thought to be regulated by interaction with inhibitory binding proteins (4E-BPs) and phosphorylation by mitogen-activated protein (MAP) kinase-interacting kinase (MNK) on Ser209 in response to mitogens and cellular stress.

MNK Isoform Specific Products:

MNK Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163479
    MNK1/2-IN-7
    		Inhibitor
    MNK1/2-IN-7 (compound 20j) is an orally available inhibitor of MNK1/2 with anticancer activity and hERG safety. MNK1/2-IN-7 also inhibits the phosphorylation of eIF4E, inhibiting the MNK/eIF4E signaling pathway and cancer cell proliferation. MNK1/2-IN-7 is synergistic with Ibrutinib (HY-109970).
    MNK1/2-IN-7
  • HY-162260
    MNK-IN-4
    		Inhibitor
    MNK-IN-4 (compound D25) is a potent and selective MNK inhibitor for the treatment of sepsis-related acute splenic injury.
    MNK-IN-4
  • HY-172457
    NUCC-0200808
    		Inhibitor
    NUCC-0200808 (Compound 12g) is an inhibitor of MNK1 with an IC50 of 42 nM. NUCC-0200808 reduces eIF4E phosphorylation and cell viability in AML cells, and induces apoptosis. NUCC-0200808 holds promise for research in the field of leukemia.
    NUCC-0200808
MNK Isoform Comparison

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