2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N10220
    Paraherquamide E
    Paraherquamide E is a fungal metabolite found in Penicillium charlesii. Paraherquamide E has antinematodal and antiparasitic effects.
    Paraherquamide E
  • HY-15731S
    Estetrol-d4
    Estetrol-d4 is the deuterium labeled Estetrol. Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast[1][2].
    Estetrol-d<sub>4</sub>
  • HY-W010388R
    Creatine (Standard)
    Creatine (Standard) is the analytical standard of Creatine. This product is intended for research and analytical applications. Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.
    Creatine (Standard)
  • HY-128747R
    α-D-Glucose-1-phosphate (disodium) (Standard)
    α-D-Glucose-1-phosphate disodium (Standard) is the analytical standard of α-D-Glucose-1-phosphate disodium (HY-128747). This product is intended for research and analytical applications. α-D-Glucose-1-phosphate disodium is used as a starting material for synthesis of glucuronic acid. α-D-Glucose-1-phosphate disodium can be used as a cytostatic compound essential for cardiopathic therapy, as an antibiotic, as an immunosuppressive agent, and as a circulatory system therapy element.
    α-D-Glucose-1-phosphate (disodium) (Standard)
  • HY-164804
    N-Lactylvaline
    		99.93%
    N-Lactylvaline is an endogenous metabolite that can be identified in patients with the intermediate type of maple syrup urine disease.
    N-Lactylvaline
  • HY-113495
    Deoxypyridinoline
    Deoxypyridinoline is an endogenous metabolite present in Urine that can be used for the research of Heart Failure.
    Deoxypyridinoline
  • HY-W017522S4
    Adipic acid-d8
    		98.64%
    Adipic acid-d8 is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].
    Adipic acid-d<sub>8</sub>
  • HY-P0259
    Xenin
    		99.25%
    Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.
    Xenin
  • HY-P2812A
    Phospholipase D, peanut
    Phospholipase D, peanut is an important signaling enzyme in mammalian cells. Phospholipase D, peanut catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) and choline .
    Phospholipase D, peanut
  • HY-136913
    (Rac)-Rhododendrol
    		99.76%
    (Rac)-Rhododendrol ((Rac)-Betuligenol) is an aromatic compound with pro-oxidant activity. (Rac)-Rhododendrol may be useful in the suppression of liver diseases. (Rac)-Rhododendrol can be toxic to melanocytes, leading to cell death. The metabolite of (Rac)-Rhododendrol, RD-quinone, is cytotoxic and causes enzyme inactivation and endoplasmic reticulum stress by binding to thiol proteins. (Rac)-Rhododendrol-derived melanin exhibits potent pro-oxidant activity and may cause oxidative stress.
    (Rac)-Rhododendrol
  • HY-167920
    Glutathione sulfonate
    Glutathione sulfonate (S-Sulfoglutathione) is a multifunctional bioactive compound that inhibits angiogenesis and tumor growth. Glutathione sulfonate is a competitive inhibitor of glutathione S-transferase and is involved in the detoxification process and the binding of a variety of exogenous and endogenous compounds. Glutathione sulfonate acts in the substrate binding site of Escherichia coli glutathione S-transferase, affecting the catalytic mechanism. The structural characteristics of Glutathione sulfonate contribute to its inhibitory effect by hydrogen bonding in the active center of the enzyme.
    Glutathione sulfonate
  • HY-N0091S6
    Hypoxanthine-d2
    		98.00%
    Hypoxanthine-d2 is the deuterium labeled Hypoxanthine[1]. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia[2].
    Hypoxanthine-d<sub>2</sub>
  • HY-Y0921S2
    (±)-1,2-Propanediol-d6
    		≥99.0%
    (±)-1,2-Propanediol-d6 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents.
    (±)-1,2-Propanediol-d<sub>6</sub>
  • HY-114464S
    11-Beta-hydroxyandrostenedione-d4
    11-Beta-hydroxyandrostenedione-d4 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor[1][2].
    11-Beta-hydroxyandrostenedione-d<sub>4</sub>
  • HY-109506S1
    DPPC-d9
    DPPC-d9 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].
    DPPC-d<sub>9</sub>
  • HY-B0941S
    6-Benzylaminopurine-d5
    		≥98.0%
    6-Benzylaminopurine-d5 is the deuterium labeled 6-Benzylaminopurine. 6-Benzylaminopurine is a cytokinin[1].
    6-Benzylaminopurine-d<sub>5</sub>
  • HY-128754S
    Monoolein-d5
    		99.72%
    Monoolein-d5 is the deuterium labeled Monoolein. Monoolein is an endogenous metabolite.
    Monoolein-d<sub>5</sub>
  • HY-N0092R
    Inosine (Standard)
    Inosine (Standard) is the analytical standard of Inosine. This product is intended for research and analytical applications. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors. In Vitro:Inosine dose-dependently stimulates cAMP production mediated through the A2AR.
    Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation.
    Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes.
    In Vivo:Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice.
    Inosine (Standard)
  • HY-W010450R
    Thymine (Standard)
    Thymine (Standard) is the analytical standard of Thymine. This product is intended for research and analytical applications. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
    Thymine (Standard)
  • HY-I0960S
    Uracil-13C2,15N2
    Uracil-13C2,15N2 is the 13C-labeled and 15N-labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
    Uracil-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N<sub>2</sub>
Cat. No. Product Name / Synonyms Application Reactivity