2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. NAMPT
  5. NAMPT Degrader

NAMPT Degrader

NAMPT Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-163440
    PROTAC NAMPT Degrader-1
    		Degrader
    PROTAC NAMPT Degrader-1 is a potent PROTAC targeting NAMPT with aDC50 value of 217 nM. PROTAC NAMPT Degrader-1 has anti-proliferative activity with an IC50 value of 0.12μM against A2780 cells. (Srtucture Note: PINK, NAMPT activator (HY-163445); Blue, VHL ligand (HY-163440); Black, linker).
  • HY-155506
    NAMPT degrader-3
    		Degrader
    NAMPT degrader-3 (compound C5) is a NAMPT degrader, depending on VHL- and proteasome manner. NAMPT degrader-3 displays cytotoxicity and inhibits A2780 cells proliferation.