2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Neprilysin
  5. Neprilysin Antagonist

Neprilysin Antagonist

Neprilysin Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-19876
    PL37
    		Antagonist
    PL37 (Debio-0827) is an orally active Enkephalinase dual inhibitor (dual inhibition refers to the simultaneous inhibition of Neutral Endopeptidase and Aminopeptidase N activities). PL37 exerts its anti-hyperalgesic effects by activating μ-opioid receptors (µ-opioid receptors), with an ED50 value of 13.4 mg/kg for analgesic effects in mice. PL37 can be used to study diabetic neuropathic pain.