2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PAI-1

PAI-1

Plasminogen activator inhibitor-1

PAI-1

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PAI-1 (Plasminogen activator inhibitor-1, also known as SERPINE1) is a member of serine protease inhibitor (SERPIN) family that acts as the primary inhibitor of two main mammalian plasminogen activators, urinary-type (uPA) and tissue-type (tPA). As the main negative regulator of plasminogen activation, PAI-1 is an essential factor in regulation of the physiological balance between thrombosis and fibrinolysis. PAI-1 is a labile molecule that exists in four different forms: active, latent, cleaved and target bound form.

High PAI-1 levels are associated with many cardiovascular diseases. PAI-1 also plays important roles in cell migration, adhesion, senescence, cancer invasion and tissue remodeling. Moreover, the PAI-1 level was extensively validated as the biological prognostic factor in breast cancer and as a marker of a poor prognosis in other cancers. PAI-1 is also one of the plasma biomarkers associated with nonalcoholic fatty liver disease. These associations have made PAI-1 an attractive pharmaceutical target.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-106508
    Fendosal
    		Inhibitor
    Fendosal (HP 129) is an orally active, potent non-steroidal anti-inflammatory agent. Fendosal (HP 129) is also an inhibitor of Plasminogen activator inhibitor-1 (PAI-1) .
    Fendosal
  • HY-B0236A
    6-Aminocaproic acid hydrochloride
    		Inhibitor
    6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.
    6-Aminocaproic acid hydrochloride
  • HY-B0236R
    6-Aminocaproic acid (Standard)
    		Inhibitor
    6-Aminocaproic acid (Standard) is the analytical standard of 6-Aminocaproic acid. This product is intended for research and analytical applications. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.
    6-Aminocaproic acid (Standard)
  • HY-P4341
    D-Val-Leu-Lys-AMC
    D-Val-Leu-Lys-AMC is a peptide substrate of plasmin.
    D-Val-Leu-Lys-AMC
  • HY-E70524
    Alpha 2 Antiplasmin, Human Plasma
    Alpha 2 Antiplasmin, Human Plasma is Alpha-2 antiplasmin from human plasma. Alpha-2 antiplasmin is the major circulating inhibitor of plasmin. Alpha-2 antiplasmin plays a determining role in the regulation of intravascular fibrinolysis.
    Alpha 2 Antiplasmin, Human Plasma
  • HY-122542A
    PPACK dihydrochloride
    		Inhibitor
    PPACK dihydrochloride is a plasminogen activator (rt-PA) inhibitor. PPACK dihydrochloride can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK dihydrochloride also inhibits the binding of rt-PA to plasma protease inhibitors.
    PPACK dihydrochloride
  • HY-P4338
    Glutaryl-Gly-Arg-AMC
    Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA).
    Glutaryl-Gly-Arg-AMC
  • HY-N0518R
    Toddalolactone (Standard)
    		Inhibitor
    Toddalolactone (Standard) is the analytical standard of Toddalolactone. This product is intended for research and analytical applications. Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM.
    Toddalolactone (Standard)
  • HY-N1504R
    Loureirin B (Standard)
    		Inhibitor
    Loureirin B (Standard) is the analytical standard of Loureirin B. This product is intended for research and analytical applications. Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
    Loureirin B (Standard)
  • HY-101214A
    UK-371804 hydrochloride
    UK-371804 hydrochloride (compound 24) is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.
    UK-371804 hydrochloride
  • HY-123191
    CJ-463
    		Inhibitor
    CJ-463 is a potent and selective uPA inhibitor. CJ-463 has antitumor activity.
    CJ-463
  • HY-119160
    TM5007
    		Inhibitor
    TM5007 is a poent and orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) with an IC50 of 29 μM. TM5007 enhance fibrinolysis activity and inhibits coagulation. TM5007 also prevents the fibrotic process initiated by bleomycin in mouse lung.
    TM5007
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity