2. Signaling Pathways
  3. PI3K/Akt/mTOR
  4. PDK-1
  5. PDK-1 Activator

PDK-1 Activator

PDK-1 Activators (3):

Cat. No. Product Name Effect Purity
  • HY-15967
    PS48
    		Activator 99.71%
    PS48 is an activator of PDK1 with an AC50 of 8 μM.
  • HY-121629
    PS210
    		Activator 98.30%
    PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K.
  • HY-135773
    CRTh2 antagonist 3
    		Activator
    CRTh2 antagonist 3 is a potent chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) antagonist. CRTh2 antagonist 3 enhances the activity of PDK1 toward a short peptide substrate, with an EC50 of 2 μM and a Kd of 8.4 μM. CRTh2 antagonist 3 has the potential for cardiovascular inflammation.