2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PI4P5K

PI4P5K

Phosphatidylinositol 4-phosphate 5-kinases

Phosphatidylinositol 4-phosphate 5-kinases (PI4P5K) are a class of enzymes that phosphorylate phosphatidylinositol 4-phosphate. Phosphatidylinositol 4-phosphate 5-kinases phosphorylate phosphatidylinositol 4-phosphate (PI4P) in the 5-position to form phosphatidylinositol 4,5-bisphosphate (PI45P2). There are two types of phosphatidylinositol 4-phosphate 5-kinases found which includes Type I and Type II. Murine PI4P5K type Ibeta (mPIP5K-Ibeta) was implicated in receptor mediated endocytosis through the isolation of a truncated and inactive form of the enzyme that blocked the ligand-dependent downregulation of the colony-stimulating factor-1 receptor. Phosphatidylinositol 4-phosphate 5-kinases regulate diverse cellular processes such as G protein-coupled receptor(GPCR) signaling, vesicle trafficking, chemotaxis and cellular movement[1][2].

PI4P5K Related Products (4):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16937
    ISA-2011B
    		Inhibitor 99.85%
    ISA-2011B is a PIP5K1α inhibitor with promising anticancer effects .
    ISA-2011B
  • HY-163476
    PIP5K1C-IN-1
    		Inhibitor
    PIP5K1C-IN-1 (Compound 30) is a potent PIP5K1C inhibitor, with an IC50 of 0.80 nM. PIP5K1C-IN-1 exhibits low total clearance in mice and high levels of kinase selectivity. PIP5K1C-IN-1 can be used for the research of cancer and chronic pain.
    PIP5K1C-IN-1
  • HY-163572
    PIP5K1α-IN-1
    		Inhibitor
    PIP5K1α-IN-1 (Compound 3e) is an inhibitor for phosphatidylinositol 4-phosphate 5-kinase type I α (PIP5K1α) with an IC50 of 0.46 μM.
    PIP5K1α-IN-1
  • HY-163477
    PIP5K1C-IN-2
    		Inhibitor
    PIP5K1C-IN-2 (compound 33) is a potent and selective 4-phosphate 5-kinases 1 C (PIP5K1C) inhibitor with an IC50 value of 0.0059 µM.
    PIP5K1C-IN-2