Pantetheinase

Pantetheinase is a ubiquitous enzyme that hydrolyzes D-pantothenic acid to cysteamine and pantothenic acid (vitamin B5) through the dissimilating pathway of coenzyme A^[1]. The pantetheinase is encoded by the Vnn (vanin) gene, with Vnn1 being the dominant tissue subtype in both mice and humans^[2]. Under physiological conditions, membrane-bound pantetheinase is the main source of cysteamine in tissues. Cysteamine is a potent antioxidant, and Vanin/pantetheinase may be involved in the regulation of certain immune functions. Pantothenic acid is an important component of coenzyme A biosynthesis, and coenzyme A is a crucial cofactor involved in the tricarboxylic acid cycle and fatty acid metabolism. Mercaptoethylamine inhibits glutamylcysteine synthetase, thereby reducing the glutathione pool, which may trigger an inflammatory response. Additionally, functional studies of the enzyme have also shown that pantetheinase is involved in liver lipid metabolism, gluconeogenesis, and inflammation^[3].

References:

[1]. Naquet P, et al. Role of the Vnn1 pantetheinase in tissue tolerance to stress. Biochem Soc Trans. 2014 Aug;42(4):1094-100.

[2]. Pitari G, et al. Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice. FEBS Lett. 2000 Oct 20;483(2-3):149-54. [Content Brief]

[3]. Rommelaere S, et al. Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria. Am J Pathol. 2015 Nov;185(11):3039-52. [Content Brief]

[4]. Naquet P, et al. Role of the Vnn1 pantetheinase in tissue tolerance to stress. Biochem Soc Trans. 2014 Aug;42(4):1094-100. [Content Brief]

Pantetheinase Inhibitors (8)

Pantetheinase Related Products (8):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-18780

RR6	Inhibitor	99.65%
RR6 is a potent, selective, reversible, competitive and orally active vanin inhibitor with an IC₅₀ of 540 nM for recombinant vanin-1. RR6 also potently inhibits human, bovine and rat serum pantetheinase with IC₅₀ values of 40 nM, 41 nM and 87 nM, respectively.

HY-129035

PFI-653	Inhibitor	99.92%
PFI-653 (Vanin-1-IN-1, compound 3) is a vanin-1 inhibitor that binds to plasma vanin-1 from mouse, rat, dog, and human. Vanin-1 is a cell surface-associated inositol (GPi) -anchored protein that plays important roles in metabolism and inflammation. PFI-653 inhibits vanin-1 from different species with IC₅₀s of 6.85 nM (human recombinant plasma vanin-1), 9.0 nM (human plasma vanin-1), 24.5 nM (mouse recombinant vanin-1), and 53.4 nM (mouse plasma vanin-1).

HY-146412

Vanin-1-IN-3	Inhibitor
Vanin-1-IN-3 (OMP-7) is a vanin-1 inhibitor with an IC₅₀ of 0.038 μM.

HY-161249

Vanin-1-IN-4	Inhibitor
Vanin-1-IN-4 (compound (S)-1) is vanin-1 inhibitor with a chiral methyl substituent, with profils as potent drug-candidate but exist as an amorphous solid.

HY-149594

CL-Pa	Inhibitor
CL-Pa is a chemiluminescent probe suitable for detection of urinary Vanin-1. CL-Pa can be used to detect drug-induced acute kidney injury (AKI) through urinalysis.

HY-159986

X-17	Inhibitor
X-17 is a Vanin-1 Inhibitor with potent anti-inflammatory and antioxidant activities. X-17 repressrs the inflammatory factor expressions and myeloperoxidase activity, elevats the colonic glutathione reserve, and restors the intestinal barrier.

HY-145316

Vanin-1-IN-2	Inhibitor
Vanin-1-IN-2 is a potent vanin-1 inhibitor with an IC₅₀ of 162 nM. Vanin-1 is a cell-surface-associated, glycosylphosphatidyl inositol (GPI)-anchored protein which is expressed at high levels in the kidney, liver, and small intestine.

HY-N1220

Stephavanine	Inhibitor
Stephavanine is a compound isolated from the roots of Stephania abyssinica.

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