2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor
  5. Prostaglandin Receptor Agonist

Prostaglandin Receptor Agonist

Prostaglandin Receptor Isoform Comparison

Prostaglandin Receptor Agonists (153):

Cat. No. Product Name Effect Purity
  • HY-121091
    EP2 receptor agonist 4
    		Agonist
    EP2 receptor agonist 4 is a selective agonist for EP2 receptor with an EC50 of 43 nM.
  • HY-116250
    Prostaglandin D2-1-glyceryl ester
    		Agonist
    Prostaglandin D2-1-glyceryl ester (PGD2-G; PGD2 2-glyceryl ester).
  • HY-19641
    AH13205
    		Agonist
    AH13205 is a selective prostanoid EP2-receptor agonist. AH13205 causes concentration-related relaxations of Carbachol (HY-B1208)-contracted trachea. AH13205 causes dose-related protection against Histamine (HY-B1204)-induced increases in respiratory rate.
  • HY-137574
    19(R)-Hydroxy prostaglandin E1
    		Agonist
    19(R)-Hydroxy prostaglandin E1 (19(R)-Hydroxy PGE1), the major prostaglandin in primate semen, is an agonist of EP1 and EP3 receptor subtypes and exhibits contractile activity on smooth muscle preparations.
  • HY-19255
    FK-788
    		Agonist
    FK-788 is a PGI(2) and IP agonist with a strong anti-aggregation effect, with an IC50 of 18 nM and a high binding affinity for the human recombinant IP receptor, with a Ki value of 20 nM.
  • HY-123328
    AGN 191976
    		Agonist
    AGN 191976 is a potent and selective thromboxane A2-sensitive (TP) receptor agonist with EC50 values ​​of 0.23 nM and 24 nM in rat aorta and human platelets, respectively. AGN 191976 has potent IOP-lowering effects in dogs and monkeys. AGN 191976 can be used to study vascular biology and the role of thromboxane A2 in vascular function.
  • HY-168382A
    5S(6R)-EET
    		Agonist
    5S(6R)-EET is the metabolite of Arachidonic acid (HY-109590). 5S(6R)-EET activates the synthesis of endogenous prostaglandin (PGE2), which inhibits the Na+ absorption, increases the intracellular Ca2+, and promotes the depolarization of transmembrane voltage. 5S(6R)-EET is more active than 5R(6S)-EET (HY-168382).
  • HY-105315
    AFP-07
    		Agonist
    AFP-07 is a derivative of 7, 7-difluoroprostacyclic and is a highly potent and selective prostacyclin receptor IP receptor agonist with a Ki value of 0.561 nM.
  • HY-160993
    Ciprostene
    		Agonist
    Ciprostene is analog of prostacyclin (PGI2). Ciprostene inhibits adenosine diphosphate-induced platelet aggregation. Ciprostene can be used for research of peripheral vascular disease.
  • HY-14870R
    Selexipag (Standard)
    		Agonist
    Selexipag (Standard) is the analytical standard of Selexipag. This product is intended for research and analytical applications. Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor).
  • HY-16504S
    Treprostinil-13C2,d1 Sodium
    		Agonist
    Treprostinil-13C2-d1 (Sodium) (UT-15-13C2-d1(sodium)) is deuterium and 13C labeled Treprostinil (sodium). Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
  • HY-108936
    QCC374
    		Agonist
    QCC374 is a selective agonist of IP.
  • HY-107381R
    (+)-Cloprostenol (Standard)
    		Agonist
    (+)-Cloprostenol (Standard) is the analytical standard of (+)-Cloprostenol. This product is intended for research and analytical applications. (+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.
  • HY-A0096R
    Iloprost (Standard)
    		Agonist
    Iloprost (Standard) is the analytical standard of Iloprost. This product is intended for research and analytical applications. Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research.
  • HY-N6070R
    Ricinoleic acid (purity≥85%) (Standard)
    		Agonist
    Ricinoleic acid (purity≥85%) (Standard) is the analytical standard of Ricinoleic acid (purity≥85%). This product is intended for research and analytical applications. Ricinoleic acid (purity≥85%), a hydroxy fatty acid, is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Ricinoleic acid is the main active ingredient of Castor oil (HY-107799). Ricinoleic acid is the agonist for prostaglandin EP3 receptor (EP3 receptor) (EC50 in MEG-01 is 0.5 μM), that causes laxative effects and uterine contraction. Ricinoleic acid exhibits antianxiety-like, anti-inflammatory and pro-inflammatory properties.
  • HY-79593S3
    MRE-269-d7 sodium
    		Agonist
    MRE-269-d7 (ACT-333679-d7) sodium is deuterium-labeled MRE-269 (HY-79593).
  • HY-106699
    Taprostene sodium
    		Agonist
    Taprostene sodium is a partial agonist at prostanoid prostacyclin (IP) receptors. Taprostene sodium interacts additively with Prostaglandin E2 (PGE2) (HY-101952), ONO-AE1-259 (selective EP2 agonist), and acetylcholine. Taprostene sodium exerts a significant cardioprotection.
  • HY-124243
    N-Cyclopropyl methyl bimatoprost
    		Agonist
    N-Cyclopropyl methyl bimatoprost (17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide) is an analog of Bimatoprost (HY-12956). N-Cyclopropyl methyl bimatoprost is an agonist for Prostaglandin F2α Receptor (FP receptor). N-Cyclopropyl methyl bimatoprost is potent to reduce the intraocular pressure and attenuate the glaucoma.
  • HY-137043
    9-Keto Travoprost
    		Agonist
    9-Keto Travoprost is a derivative of Fluprostenol (HY-108560). 9-Keto Travoprost is an EP receptor agonist. 9-Keto Travoprost can be used in endocrine-related research.
  • HY-130448
    8-iso Prostaglandin F1β
    		Agonist
    8-iso Prostaglandin F1β is an isoprostane, that exhibits vasoconstrictive effect in neonatal porcine pulmonary arteries, pulmonary veins, and mesenteric arteries. 8-iso Prostaglandin F1β targets TXA2 receptor and exhibits the blood vessel contractile efficacy under the influence of tyrosine kinase and Rho kinase.