2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. Src
  5. Fyn Isoform
  6. Fyn Inhibitor

Fyn Inhibitor

Fyn Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-118105
    RK-20448
    		Inhibitor 99.38%
    RK-20448 is an ATP-competitive inhibitor of Lck, Src, VEGFR2/KDR/Flk-1/VEGF2R and Tie-2 with IC50 values of 0.24, 1.19, 10.74 and 5.85 µM, respectively. RK-20448 also inhibits BLK, Csk, Fyn and Lyn with IC50 values of 0.37, 4.27, 2.03 and 0.43 µM, respectively. RK-20448 is the cis isomer of A-419259 (HY-15764).
  • HY-120622
    BMS-243117
    		Inhibitor
    BMS-243117 is a potent, and selective benzothiazole based p56Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck.