2. Protein Tyrosine Kinase/RTK
  3. Src VEGFR Tie
  4. RK-20448

RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R and Tie-2 with IC50 values of 0.24, 1.19, 10.74 and 5.85 µM, respectively. RK-20448 also inhibits BLK, Csk, Fyn and Lyn with IC50 values of 0.37, 4.27, 2.03 and 0.43 µM, respectively. RK-20448 is the cis isomer of A-419259 (HY-15764).

For research use only. We do not sell to patients.

RK-20448 Chemical Structure

RK-20448 Chemical Structure

CAS No. : 479501-40-1

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 212 In-stock
Solution
10 mM * 1 mL in DMSO USD 212 In-stock
Solid
5 mg USD 200 In-stock
10 mg USD 360 In-stock
25 mg USD 800 In-stock
50 mg USD 1325 In-stock
100 mg USD 2120 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

RK-20448 Related Antibodies

Top Publications Citing Use of Products

View All Src Isoform Specific Products:

View All Isoforms
Lck Fyn Blk

View All VEGFR Isoform Specific Products:

View All Isoforms
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

View All Tie Isoform Specific Products:

View All Isoforms
Tie2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R and Tie-2 with IC50 values of 0.24, 1.19, 10.74 and 5.85 µM, respectively. RK-20448 also inhibits BLK, Csk, Fyn and Lyn with IC50 values of 0.37, 4.27, 2.03 and 0.43 µM, respectively. RK-20448 is the cis isomer of A-419259 (HY-15764)[1][2].

IC50 & Target

Lck

0.24 μM (IC50)

Blk

0.37 μM (IC50)

Fyn

2.03 μM (IC50)

Tie2

5.85 μM (IC50)

VEGFR2

10.74 μM (IC50)

Molecular Weight

482.62

Formula

C29H34N6O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=C(C2=NC=N1)C(C3=CC=C(C=C3)OC4=CC=CC=C4)=CN2[C@H]5CC[C@H](CC5)N6CCN(CC6)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (51.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0720 mL 10.3601 mL 20.7202 mL
5 mM 0.4144 mL 2.0720 mL 4.1440 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0720 mL 10.3601 mL 20.7202 mL 51.8006 mL
5 mM 0.4144 mL 2.0720 mL 4.1440 mL 10.3601 mL
10 mM 0.2072 mL 1.0360 mL 2.0720 mL 5.1801 mL
15 mM 0.1381 mL 0.6907 mL 1.3813 mL 3.4534 mL
20 mM 0.1036 mL 0.5180 mL 1.0360 mL 2.5900 mL
25 mM 0.0829 mL 0.4144 mL 0.8288 mL 2.0720 mL
30 mM 0.0691 mL 0.3453 mL 0.6907 mL 1.7267 mL
40 mM 0.0518 mL 0.2590 mL 0.5180 mL 1.2950 mL
50 mM 0.0414 mL 0.2072 mL 0.4144 mL 1.0360 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

RK-20448 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RK-20448479501-40-1RK20448RK 20448SrcVEGFRTieVascular endothelial growth factor receptorAngiopoietin receptorLckKDR/VEGF2RTie-2BLKCskFynLynInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
RK-20448
Cat. No.:
HY-118105
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.