2. Signaling Pathways
  3. Apoptosis
  4. TNF Receptor
  5. TNF Receptor Isoform
  6. TNF Receptor Ligand

TNF Receptor Ligand

TNF Receptor Ligands (4):

Cat. No. Product Name Effect Purity
  • HY-P991180
    TRX-518
    		Ligand
    TRX-518 is a humanized agonist antibody targeting glucocorticoid-induced tumor necrosis factor receptor (GITR). TRX-518 specifically targets GITR⁺ Tregs and CD45RA⁻Foxp3⁺ effector Tregs (eTregs) among regulatory T cells (Tregs), reducing the number of Tregs in circulation and within tumors. TRX-518 is promising for research of cancers.
  • HY-P991194
    HFB-200301
    		Ligand
    HFB-200301 is an IgG1 antibody targeting tumor necrosis factor receptor 2 (TNFR2). HFB-200301 promotes the activation of TNFR2, thereby activating relevant signaling pathways, such as activating RelA and cRel-containing NF-κB dimers through the classical NF-κB pathway, affecting cell metabolism and gene expression in the presence of sTNF. HFB-200301 is promising for research of cancers.
  • HY-P991126
    Ciltistotug
    		Ligand
    Ciltistotug is a monoclonal antibody targeting human CD40 (TNFRSF5). Ciltistotug activates immune cells after binding to CD40, exerting immunostimulatory and antitumor activities. Ciltistotug is promising for research of cancer immunotherapy.
  • HY-P991125
    Cenzestotug
    		Ligand
    Cenzestotug is a monoclonal antibody targeting human tumor necrosis factor receptor superfamily member 4 (TNFRSF4). Cenzestotug activates relevant immune cells by binding to TNFRSF4, exerting immunostimulatory and antitumor activities. Cenzestotug is promising for research of cancer immunotherapy.