2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Thrombin

Thrombin

Thrombin

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Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117561
    DuP 714
    		Inhibitor
    DuP 714 is an oral active thrombin inhibitor with the IC50 values of 150 nM aganist thrombin-induced aggregation in washed human platelets. DuP 714 can be used for study of arterial thrombosi.
    DuP 714
  • HY-117798
    LY 806303
    		Inhibitor
    LY 806303 is a potent and selective inhibitor of human α-thrombin. LY 806303 specifically acylates Ser-205 within the catalytic triad of α-thrombin on the heavy chain and a key site involved in the enzymatic activity of thrombin. The mechanism of action of LY 806303 as an enzyme inhibitor is through the specific acylation of this catalytic serine residue.
    LY 806303
  • HY-B0375AR
    Argatroban (monohydrate) (Standard)
    		Inhibitor
    Argatroban (monohydrate) (Standard) is the analytical standard of Argatroban (monohydrate). This product is intended for research and analytical applications. Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor.
    Argatroban (monohydrate) (Standard)
  • HY-136898
    PS-915 dihydrochloride
    PS-915 dihydrochloride is a peptide substrate used in a colorimetric assay for plasma antithrombin III (ATIII). PS-915 dihydrochloride is highly specific for thrombin. By enzyme hydrolysis, PS-915 dihydrochloride liberates 3-carboxy-4-hydroxyaniline (CHA), which turns blue in color due to the complex formation with added alkaline-pentacyanoammine ferroate.
    PS-915 dihydrochloride
  • HY-148826
    Rovunaptabin
    		Inhibitor
    Rovunaptabin (ARC 183) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.
    Rovunaptabin
  • HY-12605S
    SAR107375-d11 Tartrate
    		Inhibitor
    SAR107375-d11 (Tartrate) is deuterium labeled SAR107375. SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with Ki values of 1 nM and 8 nM for factor Xa and thrombin, respectively.
    SAR107375-d<sub>11</sub> Tartrate
  • HY-108739
    Idarucizumab
    		Activator
    Idarucizumab is a humanized monoclonal antibody fragment. Idarucizumab is first reversal agent for a direct oral anticoagulant (DOAC). Idarucizumab can specifically neutralize the effects of the oral direct thrombin inhibitor in order to restore hemostasis.
    Idarucizumab
  • HY-19442
    Idrabiotaparinux
    Idrabiotaparinux, a derivative of Idraparinux (HY-19691), is a novel synthetic anticoagulant that links Idraparinux, a specific, indirect factor Xa inhibitor, to biotin.
    Idrabiotaparinux
  • HY-10274AR
    Dabigatran etexilate (mesylate) (Standard)
    		Inhibitor
    Dabigatran etexilate (mesylate) (Standard) is the analytical standard of Dabigatran etexilate (mesylate). This product is intended for research and analytical applications. Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.
    Dabigatran etexilate (mesylate) (Standard)
  • HY-P2021
    BMS 180742
    		Inhibitor
    BMS 180742 is a thrombin exosite inhibitor. BMS 180742 does not inhibit arterial thrombosis.
    BMS 180742
  • HY-19219A
    BMS-189664 hydrochloride
    		Inhibitor
    BMS-189664 hydrochloride is a potent, selective, and orally active reversible inhibitor of a-thrombin, with an IC50 of 0.046 μM. BMS-189664 hydrochloride can be used for arterial and venous thrombosis research.
    BMS-189664 hydrochloride
  • HY-118177
    Neutrophil elastase inhibitor 1
    		Inhibitor
    Neutrophil elastase inhibitor 1 (Compound 5b) is a competitive, pseudoirreversible inhibitor for neutrophil elastase with an IC50 of 7 nM.
    Neutrophil elastase inhibitor 1
  • HY-N15271
    Oxopurpureine
    Oxopurpureine is an oxoaporphine with antiplatelet aggregation activity. Oxopurpureine inhibits collagen, thrombin and arachidonic acid-induced platelet aggregation and can be utilized in relevant research.
    Oxopurpureine
  • HY-19219
    BMS-189664
    		Inhibitor
    BMS-189664 is a potent, selective, and orally active reversible inhibitor of a-thrombin, with an IC50 of 0.046 μM. BMS-189664 can be used for arterial and venous thrombosis research.
    BMS-189664
  • HY-161867
    Platelet aggregation-IN-1
    Platelet aggregation-IN-1 (Compound 10e) is an inhibitor for platelet aggregation, that inhibits 100% thrombin-induced platalet aggregation at 50 μM.
    Platelet aggregation-IN-1
  • HY-116913
    Moxicoumone
    		Inhibitor
    Moxicoumone is an anticoagulant.
    Moxicoumone
  • HY-15759A
    Napsagatran hydrate
    		Inhibitor
    Napsagatran hydrate is a novel and specific thrombin inhibitor.
    Napsagatran hydrate
  • HY-19660
    Inogatran
    		Inhibitor
    Inogatran (H-314-27) is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of arterial and venous thrombotic diseases.
    Inogatran
  • HY-10264R
    Edoxaban (Standard)
    		Inhibitor
    Edoxaban (Standard) is the analytical standard of Edoxaban. This product is intended for research and analytical applications. Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research.
    Edoxaban (Standard)
  • HY-10275
    Atecegatran
    		Inhibitor
    Atecegatran (AR-H067637) is an orally active competitive thrombin inhibitor with a Ki of 2-4 nM. AR-H067637 inhibits platelet activation and aggregation by blocking thrombin binding to fibrin and thrombomodulin. Atecegatran demonstrates significant anticoagulant effects in various plasma coagulation assays, with an IC50 ranging from 93 to 220 nM. Atecegatran can be used in research related to thromboembolic disorders.
    Atecegatran
Cat. No. Product Name / Synonyms Application Reactivity