2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. UGT

UGT

UDP-glucuronosyltransferase; Uridine diphosphate glucuronosyltransferase

UGT is a type of catabolic enzyme that belongs to the family of detoxification enzymes. UGT consists of two subfamilies, UGT1 and UGT2. UGT1 consists of 5 exons and has a unique gene structure. There are thirteen exon 1s from UGT1A1 to UGT1A13P, and exon 2 to exon 5 are used in common for all mRNAs expressed from the gene. Each isoform of UGT1 results from differential splicing of exon1s to common exon 2-5, and has an unique spectrum of substrate specificity. In contrast, the genes of the UGT2 family consist of 6 exons, and all the enzymes have an individual set of exon 1 to exon 6. UGT involves in the detoxification and excretion of many xenobiotic and endogeneous substances in intrahepatic and extrahepatic tissues. The mutations of UGT1A1 cause hereditary unconjugated hyperbilirubinemias: Crigler-Najjar syndrome type I, type II and Gilbert syndrome.

UGT Related Products (17):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0235
    Bakuchiol
    		Inhibitor 99.25%
    Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC50s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory, antibacterial, antitumor therapies, as well as drug metabolism regulation.
    Bakuchiol
  • HY-131703
    UGT8-IN-1
    		Inhibitor 99.94%
    UGT8-IN-1 is a brain penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8). UGT8-IN-1 can be used in the study for lysosomal storage disorders.
    UGT8-IN-1
  • HY-B0811
    Salicylamide
    		Inhibitor 99.92%
    Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent.
    Salicylamide
  • HY-111832
    1,2,3,6-Tetragalloylglucose
    		Inhibitor 99.18%
    1,2,3,6-Tetragalloylglucose is a potent UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) inhibitor, with a Ki of 1.68 μM.
    1,2,3,6-Tetragalloylglucose
  • HY-N0897
    Corylifol A
    		99.90%
    Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.
    Corylifol A
  • HY-137979
    Flunitrazolam
    Flunitrazolam is an orally active designer Benzodiazepine. Flunitrazolam is biologically toxic, class in psychoactive substances.
    Flunitrazolam
  • HY-N0859
    Schisanhenol
    		Inhibitor 99.99%
    Schisanhenol is a natural compound solated from Schisandra rubriflora; UGT2B7 UDP-glucuronosyltransferases inhibitor.
    Schisanhenol
  • HY-137083
    Trifluoperazine N-Glucuronide
    		Inhibitor
    Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation.
    Trifluoperazine N-Glucuronide
  • HY-160250
    UGT1A1-IN-1
    		99.27%
    UGT1A1-IN-1 (compound 2) is a non-competitive inhibitor of UGT1A1, which can inhibit the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. UGT1A1-IN-1 (compound 2) can bind on UGT1A1 at the same ligand-binding site as bilirubin (HY-N0323). UGT1A1-IN-1 can serve as a ‘turn-on’ fluorescent probe substrate for UGT1A1.
    UGT1A1-IN-1
  • HY-N2413
    Gomisin D
    		Inhibitor 99.41%
    Gomisin D, a lignan compound isolated from Fructus Schisandra, is a potential antidiabetic and anti-Alzheimer’s agent. Gomisin D inhibits UDP-Glucuronosyltransferases activity and scavenges ABTS(+) radicals. Gomisin D is used as a quality marker of Shengmai San and shenqi Jiangtang Granule.
    Gomisin D
  • HY-N12360A
    2,3-Dehydrosilybin B
    		98.11%
    2,3-Dehydrosilybin B is an enantiomer formed by the oxidation of the natural flavonolignans silybin A.
    2,3-Dehydrosilybin B
  • HY-100319
    UK-157147
    		Inhibitor
    UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a Km value of 105 μM.
    UK-157147
  • HY-N0859R
    Schisanhenol (Standard)
    		Inhibitor
    Schisanhenol (Standard) is the analytical standard of Schisanhenol. This product is intended for research and analytical applications.
    Schisanhenol (Standard)
  • HY-136653
    Ciramadol
    		Activator
    Ciramadol (WY 15705) is a potent and orally active analgesic agent with both narcotic agonist and UDP-glucuronyltransferase modulator properties. Ciramadol (WY 15705) can be used for postoperative pain research research.
    Ciramadol
  • HY-N0235R
    Bakuchiol (Standard)
    		Inhibitor
    Bakuchiol (Standard) is the analytical standard of Bakuchiol. This product is intended for research and analytical applications. Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC50s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory, antibacterial, antitumor therapies, as well as drug metabolism regulation.
    Bakuchiol (Standard)
  • HY-N0897R
    Corylifol A (Standard)
    Corylifol A (Standard) is the analytical standard of Corylifol A. This product is intended for research and analytical applications. Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.
    Corylifol A (Standard)
  • HY-108292R
    Propacetamol (hydrochloride) (Standard)
    		Activator
    Propacetamol (hydrochloride) (Standard) is the analytical standard of Propacetamol (hydrochloride). This product is intended for research and analytical applications. Propacetamol hydrochloride is an analgesic agent. Propacetamol hydrochloride also is a precursor form of paracetamol. Propacetamol hydrochloride can be used in postoperative pain, acute trauma and gastrointestinal disorders.
    Propacetamol (hydrochloride) (Standard)