2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. VD/VDR
  5. VD/VDR Antagonist

VD/VDR Antagonist

VD/VDR Antagonists (3):

Cat. No. Product Name Effect Purity
  • HY-147337
    MeTC7
    		Antagonist 98.52%
    MeTC7 is a Vitamin-D receptor (VDR) antagonist. MeTC7 has potent VDR inhibition activity with an IC50 value of 2.9 μM. MeTC7 shows good antitumor effects.
  • HY-12407
    ZK168281
    		Antagonist ≥98.0%
    ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3 analog and a pure VDR antagonist with a Kd value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor.
  • HY-12397
    ZK159222
    		Antagonist 98.27%
    ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character.