2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. VEGFR
  5. VEGFR1/Flt-1 Isoform
  6. VEGFR1/Flt-1 Antagonist

VEGFR1/Flt-1 Antagonist

VEGFR1/Flt-1 Antagonists (2):

Cat. No. Product Name Effect Purity
  • HY-P10833
    VGB3
    		Antagonist
    VGB3 is an antagonist peptide of vascular endothelial growth factor receptor 1 (VEGFR1/Flt-1)/VEGFR2/KDR/Flk-1 with antiangiogenic and antitumor effects. VGB3 binds to both VEGFR1/Flt-1 and VEGFR2/KDR/Flk-1, thereby inhibits VEGF-driven proliferation, migration and tube formation of endothelial cells, and tumor growth and metastasis in murine 4T1 mammary carcinoma tumor model.
  • HY-P10831
    GNQWFI
    		Antagonist
    GNQWFI, an anti-Flt1 peptide, is a VEGFR1/Flt-1-specific antagonist. GNQWFI blocks the interaction of VEGFR1/Flt-1 with various VEGFR1/Flt-1 ligands, such as VEGFA, VEGFB, and placental growth factor (PIGF) and inhibits VEGF-induced endothelial cell migration and tube formation. GNQWFI is promising for research of cancer, asthma, and other ocular diseases.