Wee1 Inhibitor

Wee1 Inhibitors (28):

Cat. No.	Product Name	Effect	Purity

HY-10993

Adavosertib	Inhibitor	99.97%
Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC₅₀ of 5.2 nM.

HY-145817A

lunresertib	Inhibitor	99.90%
lunresertib (RP-6306) is a potent, selective and orally active PKMYT1 inhibitor with an IC₅₀ of 14 nM. lunresertib shows a high degree of selectivity over other kinases in cellular binding assays. lunresertib shows anticancer effects.

HY-132295

Azenosertib	Inhibitor	99.96%
Azenosertib (ZN-c3) is a selective, orally active inhibitor for Wee1 inhibitor (IC₅₀=3.9 nM). Azenosertib exhibits antitumor activity.

HY-13925

PD0166285	Inhibitor	99.46%
PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC₅₀ values of 24 and 72 nM, respectively. PD0166285 exhibits an IC₅₀ of 3.433 μM for Chk1.

HY-18961

PD 407824	Inhibitor	98.02%
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC₅₀s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4.

HY-161879

WEE1-IN-9	Inhibitor
WEE1-IN-9 (Compound 1) is a Wee1 inhibitor that can be used in cancer research.

HY-161880

WEE1-IN-10	Inhibitor
WEE1-IN-10 (compound 77) is a Wee1 kinase inhibitor. WEE1-IN-10 shows inhibitory activity on LOVO cell growth, with an IC₅₀ of 0.524 μM. WEE1-IN-10 can be used for the research of diseases caused by abnormal activity of Wee1.

HY-147054

WEE1-IN-5	Inhibitor	99.90%
WEE1-IN-5 is a potent WEE1 inhibitor with an IC₅₀ value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer.

HY-122113

PD173952	Inhibitor	99.44%
PD173952 is a tyrosine kinases inhibitor with IC₅₀s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a K_i of 8.1 nM. PD173952 induces apoptosis.

HY-145817

(Rac)-lunresertib	Inhibitor	99.72%
(Rac)-lunresertib (compound 181) is a potent Myt1 inhibitor with an IC₅₀ of <10 nM. (Rac)-lunresertib (compound 181) has anticancer effects.

HY-145817B

(R)-lunresertib	Inhibitor	99.87%
(R)-lunresertib can be used for the research of Myt1 mediated diseases and kinds of cancer for slowing the progression of cancer. (R)-lunresertib (IC₅₀=1360nM) is less active than (S)-lunresertib (IC₅₀<10nM).

HY-108343

WEE1-IN-4	Inhibitor	99.60%
WEE1-IN-4 is a potent checkpoint Wee1 kinase inhibitor with an IC₅₀ of 0.011 μM.

HY-138239

WEE1-IN-3	Inhibitor	98.64%
WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC₅₀ of <10 nM. WEE1-IN-3 has anticancer activities.

HY-145664

Myt1-IN-1	Inhibitor	98.97%
Myt1-IN-1 is a potent Myt1 inhibitor with an IC₅₀ of <10 nM. Myt1-IN-1 has anticancer effects (WO2021195782A1; compound 132).

HY-103029

Bosutinib isomer	Inhibitor	99.62%
Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with K_d values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively.

HY-145666

Myt1-IN-3	Inhibitor	99.14%
Myt1-IN-3 is a potent Myt1 inhibitor with an IC₅₀s of <10 nM (WO2021195782 A1, compound 95).

HY-145665

Myt1-IN-2	Inhibitor
Myt1-IN-2 is a potent Myt1 inhibitor with an IC₅₀ of <10 nM. Myt1-IN-2 has anticancer effects (WO2021195782A1; compound 28).

HY-163491

PKMYT1-IN-2	Inhibitor
PKMYT1-IN-2 (compound 2) is a potent PKMYT1 inhibitor with an IC₅₀ of 5.7 nM. PKMYT1-IN-2 inhibits the growth of HCC1569 cells with an IC₅₀ of 22 nM.

HY-160530

WEE1-IN-6	Inhibitor
WEE1-IN-6 (compound 110) is a orally active WEE1 inhibitor with an DC₅₀ value of ≦ 100 nM. WEE1-IN-6 inhibits cell proliferation.

HY-13925A

PD0166285 dihydrochloride	Inhibitor
PD0166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC₅₀ values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC₅₀ of 3.433 μM for Chk1.

Name
Email *

	Sorry, but the email address you supplied was invalid.