1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Wee1
  4. Wee1 Inhibitor

Wee1 Inhibitor

Wee1 Inhibitors (26):

Cat. No. Product Name Effect Purity
  • HY-10993
    Adavosertib
    Inhibitor 99.97%
    Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM.
  • HY-145817A
    lunresertib
    Inhibitor 99.90%
    lunresertib (RP-6306) is a potent, selective and orally active PKMYT1 inhibitor with an IC50 of 14 nM. lunresertib shows a high degree of selectivity over other kinases in cellular binding assays. lunresertib shows anticancer effects.
  • HY-13925
    PD0166285
    Inhibitor 99.46%
    PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 exhibits an IC50 of 3.433 μM for Chk1.
  • HY-132295
    Azenosertib
    Inhibitor 99.96%
    Azenosertib (ZN-c3) is a selective, orally active inhibitor for Wee1 inhibitor (IC50=3.9 nM). Azenosertib exhibits antitumor activity.
  • HY-18961
    PD 407824
    Inhibitor 98.02%
    PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4.
  • HY-163491
    PKMYT1-IN-2
    Inhibitor
    PKMYT1-IN-2 (compound 2) is a potent PKMYT1 inhibitor with an IC50 of 5.7 nM. PKMYT1-IN-2 inhibits the growth of HCC1569 cells with an IC50 of 22 nM.
  • HY-161879
    WEE1-IN-9
    Inhibitor
    WEE1-IN-9 (Compound 1) is a Wee1 inhibitor that can be used in cancer research.
  • HY-161880
    WEE1-IN-10
    Inhibitor
    WEE1-IN-10 (compound 77) is a Wee1 kinase inhibitor. WEE1-IN-10 shows inhibitory activity on LOVO cell growth, with an IC50 of 0.524 μM. WEE1-IN-10 can be used for the research of diseases caused by abnormal activity of Wee1.
  • HY-147054
    WEE1-IN-5
    Inhibitor 99.90%
    WEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer.
  • HY-122113
    PD173952
    Inhibitor 99.44%
    PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis.
  • HY-145817
    (Rac)-lunresertib
    Inhibitor 99.72%
    (Rac)-lunresertib (compound 181) is a potent Myt1 inhibitor with an IC50 of <10 nM. (Rac)-lunresertib (compound 181) has anticancer effects.
  • HY-145817B
    (R)-lunresertib
    Inhibitor 99.87%
    (R)-lunresertib can be used for the research of Myt1 mediated diseases and kinds of cancer for slowing the progression of cancer. (R)-lunresertib (IC50=1360nM) is less active than (S)-lunresertib (IC50<10nM).
  • HY-138239
    WEE1-IN-3
    Inhibitor 98.64%
    WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. WEE1-IN-3 has anticancer activities.
  • HY-108343
    WEE1-IN-4
    Inhibitor 99.60%
    WEE1-IN-4 is a potent checkpoint Wee1 kinase inhibitor with an IC50 of 0.011 μM.
  • HY-145664
    Myt1-IN-1
    Inhibitor 98.97%
    Myt1-IN-1 is a potent Myt1 inhibitor with an IC50 of <10 nM. Myt1-IN-1 has anticancer effects (WO2021195782A1; compound 132).
  • HY-103029
    Bosutinib isomer
    Inhibitor 99.62%
    Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with Kd values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively.
  • HY-145666
    Myt1-IN-3
    Inhibitor 99.14%
    Myt1-IN-3 is a potent Myt1 inhibitor with an IC50s of <10 nM (WO2021195782 A1, compound 95).
  • HY-145665
    Myt1-IN-2
    Inhibitor
    Myt1-IN-2 is a potent Myt1 inhibitor with an IC50 of <10 nM. Myt1-IN-2 has anticancer effects (WO2021195782A1; compound 28).
  • HY-160530
    WEE1-IN-6
    Inhibitor
    WEE1-IN-6 (compound 110) is a orally active WEE1 inhibitor with an DC50 value of ≦ 100 nM. WEE1-IN-6 inhibits cell proliferation.
  • HY-13925A
    PD0166285 dihydrochloride
    Inhibitor
    PD0166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1.