2. Signaling Pathways
  3. Stem Cell/Wnt
  4. YAP
  5. YAP Isoform
  6. YAP Ligand

YAP Ligand

YAP Ligand (1):

Cat. No. Product Name Effect Purity
  • HY-173150
    YAP-IN-1
    		Ligand
    YAP-IN-1 (Compound (+)-1) is an autophagy (Autophagy) inhibitor targeting YAP1. YAP-IN-1 binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM and induces its degradation via the chaperone-mediated autophagy (CMA) pathway. This process inhibits Rab7-mediated fusion of autophagosomes and lysosomes, thereby reducing overall autophagy levels without affecting lysosomal function. YAP-IN-1 holds promise for research in cancer (e.g., liver cancer, breast cancer, etc.).