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ACSS2-IN-2 is an acyl-CoA synthetase short-chain family member 2 (ACSS2) inhibitor. ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer.

For research use only. We do not sell to patients.

ACSS2-IN-2 Chemical Structure

ACSS2-IN-2 Chemical Structure

CAS No. : 2332820-04-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 In-stock
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Solid
5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 450 In-stock
50 mg USD 700 In-stock
100 mg USD 1050 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

ACSS2-IN-2 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE ACSS2-IN-2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ACSS2-IN-2 is an acyl-CoA synthetase short-chain family member 2 (ACSS2) inhibitor. ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several diseases, such as viral infection, metabolic disorders, neuropsychiatric diseases, inflammatory/autoimmune conditions and cancer[1].

IC50 & Target

IC50: 3.8 nM (ACSS2)[1]
In Vitro

ACSS2-IN-2 (Compound 261) (5 h) has ACSS2 inhibitory activity with an IC50 value of 3.8 nM in MDA-MB-468 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ACSS2-IN-2 Related Antibodies
Molecular Weight

415.39

Formula

C21H19F2N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC)C1=CC=CC(N2N=C(C)C(C(NC3=CC=CC(C(F)(F)C)=C3)=O)C2=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (240.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4074 mL 12.0369 mL 24.0738 mL
5 mM 0.4815 mL 2.4074 mL 4.8148 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4074 mL 12.0369 mL 24.0738 mL 60.1844 mL
5 mM 0.4815 mL 2.4074 mL 4.8148 mL 12.0369 mL
10 mM 0.2407 mL 1.2037 mL 2.4074 mL 6.0184 mL
15 mM 0.1605 mL 0.8025 mL 1.6049 mL 4.0123 mL
20 mM 0.1204 mL 0.6018 mL 1.2037 mL 3.0092 mL
25 mM 0.0963 mL 0.4815 mL 0.9630 mL 2.4074 mL
30 mM 0.0802 mL 0.4012 mL 0.8025 mL 2.0061 mL
40 mM 0.0602 mL 0.3009 mL 0.6018 mL 1.5046 mL
50 mM 0.0481 mL 0.2407 mL 0.4815 mL 1.2037 mL
60 mM 0.0401 mL 0.2006 mL 0.4012 mL 1.0031 mL
80 mM 0.0301 mL 0.1505 mL 0.3009 mL 0.7523 mL
100 mM 0.0241 mL 0.1204 mL 0.2407 mL 0.6018 mL
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ACSS2-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACSS2-IN-22332820-04-7Othersacyl-CoA synthetase short-chain family member 2 (ACSS2)MDA-MB-468 cellsviral infectionmetabolic disordersneuropsychiatric diseasesinflammatory/autoimmune conditionscancerInhibitorinhibitorinhibit

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