2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Carboxylesterase (CES)
  5. CES1 Isoform
  6. CES1 Inhibitor

CES1 Inhibitor

CES1 Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-173267
    hCES2A-IN-2
    		Inhibitor
    hCES2A-IN-2 (compound 14n) is an orally active, highly specific, irreversible and covalent hCES2A inhibitor with an IC50 of 0.04 nM. hCES2A-IN-2 covalently binds to hCES2A by specifically targeting the catalytic serine residue (Ser-228). hCES2A-IN-2 can significantly ameliorate Irinotecan-triggered gut toxicity (ITGT) without diminishing the anti-tumor effects of Irinotecan (HY-16562) in tumor-bearing mice.