2. Immunology/Inflammation
  3. CD22
  4. Epratuzumab

Epratuzumab  (Synonyms: Antibody hLL 2)

Cat. No.: HY-P99289 Purity: 99.53%
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COA
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Epratuzumab (Antibody hLL 2) is an anti-CD22 IgG1 monoclonal antibody. Epratuzumab is also a tumor-imaging agent and an immunomodulatory agent. Epratuzumab can induce CD22 phosphorylation. Epratuzumab has been used to research non-Hodgkin’s lymphomas (NHL) and certain autoimmune diseases.

For research use only. We do not sell to patients.

CAS No. : 205923-57-5

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Based on 1 publication(s) in Google Scholar

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Epratuzumab Related Antibodies

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Description

Epratuzumab (Antibody hLL 2) is an anti-CD22 IgG1 monoclonal antibody. Epratuzumab is also a tumor-imaging agent and an immunomodulatory agent. Epratuzumab can induce CD22 phosphorylation. Epratuzumab has been used to research non-Hodgkin’s lymphomas (NHL) and certain autoimmune diseases[1].

In Vitro

Epratuzumab binds to CD22 ECD on Biacore with a KD of 0.7 nM, and resulting CD22 phosphorylation[1]. Epratuzumab (0-100 μM; 1h) results in a dose dependent increase in CD22 internalization in Daudi lymphoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Epratuzumab Related Antibodies
Clinical Trial
Molecular Weight

146580.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Epratuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 nd
Biological Activity
  • Immobilized Siglec-2/CD22 Protein, Human can bind Epratuzumab. The EC50 for this effect is 12.52 ng/mL.
Purity & Documentation

Purity: 99.53%

SDS (251 KB)

COA (231 KB) SDS-PAGE (82 KB) SEC-HPLC (121 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Epratuzumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Epratuzumab205923-57-5Antibody hLL 2Antibody hLL2Antibody hLL-2CD22Siglec 2non-Hodgkin’s lymphomasanticancerInhibitorinhibitorinhibit

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