1. Signaling Pathways
  2. Immunology/Inflammation
  3. CD28

CD28

CD28, a cell surface glycoprotein receptor, predominantly expressed on activated T cells, belongs to the Ig superfamily and provides a critical co-stimulatory signal. Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4. CD28 interacts with the CD80 dimer with relatively high affinity and the CD86 monomer with lower affinity, mediating T cell co-stimulation in conjunction with T cell receptor (TCR) signals. CD28 drives critical intracellular biochemical events including unique phosphorylation and transcriptional signaling, metabolism, and the production of key cytokines, chemokines, and survival signals that are essential for long-term expansion and differentiation of T cells. Most importantly, treatment of mice with a soluble CD28 antagonist induced antigen-specific tolerance that prevented the progression of autoimmune diseases and organ graft rejection.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P990236
    Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)
    Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse/rat/monkey/human ICOS/CD278.
    Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)
  • HY-P990803
    Anti-Mouse CD28 Antibody (PV-1)
    Inhibitor
    Anti-Mouse CD28 Antibody (PV-1) is a kind of Armenian hamster IgG in vivo mouse antibody, targeting to CD28. The recommend isotype control of Anti-Mouse CD28 Antibody (PV-1): Armenian hamster IgG, Isotype Control (HY-P990305).
    Anti-Mouse CD28 Antibody (PV-1)
  • HY-P990793
    Anti-Mouse CD28 Antibody (D665)
    Inhibitor
    Anti-Mouse CD28 Antibody (D665) is a kind of mouse IgG1 kappa in vivo mouse antibody, targeting to CD28. The recommend isotype control of Anti-Mouse CD28 Antibody (D665): Mouse IgG1 kappa, Isotype Control (HY-P99977).
    Anti-Mouse CD28 Antibody (D665)
  • HY-162810
    ICOS-IN-1
    ICOS-IN-1 (compound 9) is an inhibitor of the interaction between ICOS and ICOS-L (IC50=29.38 μM) and has activity in recognizing immune checkpoints.
    ICOS-IN-1
  • HY-N10446
    Maydispenoid B
    Maydispenoid B is a potent immunosuppressor. Maydispenoid B can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation.
    Maydispenoid B
  • HY-P990079
    Renvistobart
    Inhibitor
    Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody.
    Renvistobart
  • HY-P99893
    Rozibafusp alfa
    Inhibitor
    Rozibafusp alfa (AMG-570) is a humanized IgG2-κ monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE).
    Rozibafusp alfa
  • HY-P990819
    Anti-Rat CD28 Antibody (JJ316)
    Inhibitor
    Anti-Rat CD28 Antibody (JJ316) is a kind of mouse IgG1 kappa in vivo mouse antibody, targeting to CD28. The recommend isotype control of Anti-Rat CD28 Antibody (JJ316): Mouse IgG1 kappa, Isotype Control (HY-P99977).
    Anti-Rat CD28 Antibody (JJ316)
  • HY-P990752
    Nezastomig
    Nezastomig is an anti-FOLH1/CD28 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Nezastomig
  • HY-169819
    Calcium influx inducer compound 634
    Activator
    Calcium influx inducer compound 634 is a calcium influx inducer. Calcium influx inducer compound 634 (10 µM) enhances the release of extracellular vesicles (EVs) from mouse bone marrow-derived dendritic cells (mBMDCs). Calcium influx inducer compound 634 (10 µM) also increases the levels of CD86 and CD80 on the surface of mBMDCs, an effect that can be blocked by the calcium release-activated calcium channel inhibitor YM-58483 (HY-100831).
    Calcium influx inducer compound 634
  • HY-N10445
    Maydispenoid A
    Maydispenoid A is a potent immunosuppressor. Maydispenoid A can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation.
    Maydispenoid A
  • HY-P990865
    Anti-CD28 Antibody (9.3)
    Inhibitor
    Anti-CD28 Antibody (9.3) is a kind of mouse IgG2a chimeric antibody, targeting to human CD28. The recommend isotype control of Anti-CD28 Antibody (9.3): Mouse IgG2a kappa, Isotype Control (HY-P99978).
    Anti-CD28 Antibody (9.3)
Cat. No. Product Name / Synonyms Application Reactivity