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  4. ACG416B

ACG416B (compound 18) is a potent inhibitor of ChoK (choline kinase) with an IC50 of 0.4 μM. ACG416B renders higher ChoK inhibitory and antiproliferative activities against the HT-29 human colon cancer cell.

For research use only. We do not sell to patients.

ACG416B Chemical Structure

ACG416B Chemical Structure

CAS No. : 795316-15-3

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Based on 1 publication(s) in Google Scholar

ACG416B Related Antibodies

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Description

ACG416B (compound 18) is a potent inhibitor of ChoK (choline kinase) with an IC50 of 0.4 μM. ACG416B renders higher ChoK inhibitory and antiproliferative activities against the HT-29 human colon cancer cell[1].

IC50 & Target

ChoK[1]
Cellular Effect
Cell Line Type Value Description References
HT-29 IC50
2.2 μM
Compound: 18
Antiproliferative activity was determined using HT-29 human colon cancer cell line
Antiproliferative activity was determined using HT-29 human colon cancer cell line
[PMID: 15481981]
Molecular Weight

708.53

Formula

C38H36Br2N4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN(C1=CC=[N+](CC2=CC(C3=CC=CC(C[N+]4=CC=C(N(C)C5=CC=CC=C5)C=C4)=C3)=CC=C2)C=C1)C6=CC=CC=C6.[Br-].[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (141.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4114 mL 7.0569 mL 14.1137 mL
5 mM 0.2823 mL 1.4114 mL 2.8227 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4114 mL 7.0569 mL 14.1137 mL 35.2843 mL
5 mM 0.2823 mL 1.4114 mL 2.8227 mL 7.0569 mL
10 mM 0.1411 mL 0.7057 mL 1.4114 mL 3.5284 mL
15 mM 0.0941 mL 0.4705 mL 0.9409 mL 2.3523 mL
20 mM 0.0706 mL 0.3528 mL 0.7057 mL 1.7642 mL
25 mM 0.0565 mL 0.2823 mL 0.5645 mL 1.4114 mL
30 mM 0.0470 mL 0.2352 mL 0.4705 mL 1.1761 mL
40 mM 0.0353 mL 0.1764 mL 0.3528 mL 0.8821 mL
50 mM 0.0282 mL 0.1411 mL 0.2823 mL 0.7057 mL
60 mM 0.0235 mL 0.1176 mL 0.2352 mL 0.5881 mL
80 mM 0.0176 mL 0.0882 mL 0.1764 mL 0.4411 mL
100 mM 0.0141 mL 0.0706 mL 0.1411 mL 0.3528 mL
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ACG416B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACG416B795316-15-3OtherspyridiniumantiproliferativeChoKHT-29Inhibitorinhibitorinhibit

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HY-122675
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