2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Factor XI
  5. Factor XI Inhibitor

Factor XI Inhibitor

Factor XI Inhibitors (4):

Cat. No. Product Name Effect Purity
  • HY-156613
    Frunexian
    		Inhibitor
    Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research.
  • HY-134005
    ISIS 416858
    		Inhibitor
    ISIS 416858, a single-stranded antisense oligodeoxynucleotide, is a potent and selective inhibitor of FXI mRNA expression.
  • HY-172400
    FXIa-IN-16
    		Inhibitor
    FXIa-IN-16 (Compound 43) is an orally active and selective Factor XIa (FXIa) inhibitor with an IC50 of 0.19 nM. FXIa-IN-16 exhibits strong anticoagulant and antithrombotic activities and shows good safety in mice. FXIa-IN-16 can be used in the research related to the treatment of thrombosis.
  • HY-143477
    Factor XI-IN-1
    		Inhibitor
    Factor XI-IN-1 (Compound 27) is a factor XI activation inhibitor with an EC50 of 25.14 nM.