2. Signaling Pathways
  3. GPCR/G Protein
  4. GLP Receptor
  5. GLP Receptor Antagonist

GLP Receptor Antagonist

GLP Receptor Antagonists (5):

Cat. No. Product Name Effect Purity
  • HY-P0264
    Exendin(9-39) amide
    		Antagonist 99.81%
    Exendin(9-39) amide (Avexitide) is a glucagon-like peptide-1 (GLP-1) antagonist that competes with endogenous GLP-1 for binding to GLP-1 receptors, thereby antagonizing the effects of excess GLP-1 secretion. Exendin(9-39) amide can be used to study postoperative hypoglycemia (PBH).
  • HY-P10318
    SHR-2042
    		Antagonist
    SHR-2042 is a selective agonist of the GLP-1 receptor.SHR-2042 improves glycemic control by activating the GLP-1 receptor, enhancing insulin secretion and inhibiting glucagon secretion. SHR-2042 combined with sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) promotes monomerization through the formation of micelles and improves oral absorption efficiency.
  • HY-P0264A
    Exendin(9-39) amide acetate
    		Antagonist
    Exendin(9-39) amide (Avexitide) acetate is a glucagon-like peptide-1 (GLP-1) antagonist that competes with endogenous GLP-1 for the GLP-1R, counteracting the effects of excessive GLP-1 secretion. Exendin(9-39) amide acetate can be utilized in Postbariatric hypoglycemia (PBH) research.
  • HY-170831
    DS79932728
    		Antagonist
    DS79932728 is an orally active inhibitor for G9a and GLP with IC50 of 12.6 nM and 75.7 nM. DS79932728 induces the production of γ-globin, thereby increasing the level of fetal hemoglobin (HbF). DS79932728 increases F-reticulocytes (F-rets) proportion and exhibits good oral absorption characteristics in cynomolgus monkey models.
  • HY-P1543
    Exendin-3
    		Antagonist 98.31%
    Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn.