1. Epigenetics GPCR/G Protein
  2. Histone Methyltransferase GLP Receptor
  3. DS79932728

DS79932728 is an orally active inhibitor for G9a and GLP with IC50 of 12.6 nM and 75.7 nM. DS79932728 induces the production of γ-globin, thereby increasing the level of fetal hemoglobin (HbF). DS79932728 increases F-reticulocytes (F-rets) proportion and exhibits good oral absorption characteristics in cynomolgus monkey models.

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DS79932728 Chemical Structure

DS79932728 Chemical Structure

CAS No. : 2757191-62-9

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Description

DS79932728 is an orally active inhibitor for G9a and GLP with IC50 of 12.6 nM and 75.7 nM. DS79932728 induces the production of γ-globin, thereby increasing the level of fetal hemoglobin (HbF). DS79932728 increases F-reticulocytes (F-rets) proportion and exhibits good oral absorption characteristics in cynomolgus monkey models[1].

Molecular Weight

311.42

Formula

C19H25N3O

CAS No.
SMILES

NC1=NC2=CC(C3=CCN(C)CCC3)=C(OC)C=C2C14CCC4

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Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DS79932728
Cat. No.:
HY-170831
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