2. Signaling Pathways
  3. HOXA

HOXA

Homeobox A

Homeobox A (HOXA) is a general term for the genes in cluster A of the Homeobox gene family. HOXA contains the homeobox sequence, which can encode the homeodomain and plays a key regulatory role in processes such as biological embryonic development and cell differentiation. During embryonic development, HOXA can regulate somite differentiation and the positioning of organ primordia, ensuring that all parts of the body develop in the correct pattern and sequence. HOXA is also of great significance for the maintenance of tissue morphology. In addition, HOXA is involved in the differentiation processes of hematopoietic cells, nerve cells, and so on. Abnormalities in HOXA genes are closely related to the occurrence and development of various diseases, including congenital diseases such as hand-foot-genital syndrome and neural tube defects like spina bifida, as well as multiple tumor diseases such as leukemia and breast cancer[1][2].

HOXA Related Products (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-153916
    TCRS-417
    		99.13%
    TCRS-417 (T417) is a small molecule compound capable of docking to the interface between PBX1 and its cognate DNA target sequence, effectively interfering with PBX1-DNA interaction. TCRS-417 can be used in the research of cancer, developmental disorders, inflammatory disorders, autoimmune diseases or neurodegenerative diseases.
    TCRS-417
  • HY-134259
    MEISi-2
    		Inhibitor 98.97%
    MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer.
    MEISi-2
  • HY-134258
    MEISi-1
    		Inhibitor 98.76%
    MEISi-1 is a homeodomain inhibitor of small molecule MEIS1 protein. MEISi-1 significantly inhibited the activity of luciferase reporter genes containing MEIS binding sites (TGACAG) and induced self-renewal of mouse and human HSCS in vitro and in vivo. MEISi-1 can be used for research in blood diseases, heart regeneration and cancer.
    MEISi-1
  • HY-132870
    MEIS-IN-2
    		Inhibitor 99.33%
    MEIS-IN-2 is a myeloid ecotropic viral integration site 1 (MEIS1) inhibitor.
    MEIS-IN-2
  • HY-132869
    MEIS-IN-1
    		Inhibitor
    MEIS-IN-1 is a potent myeloid ecotropic viral integration site (MEIS) inhibitor to induce murine and human hematopoietic stem-cell expansion.
    MEIS-IN-1
  • HY-132871
    MEIS-IN-3
    		Inhibitor
    MEIS-IN-3 is a potent myeloid ecotropic viral integration site (MEIS) inhibitor.
    MEIS-IN-3