2. Signaling Pathways
  3. Metabolic Enzyme/Protease
    PI3K/Akt/mTOR
  4. IPK Superfamily
  5. IPK Superfamily Inhibitor

IPK Superfamily Inhibitor

IPK Superfamily Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-150607
    UNC7467
    		Inhibitor 98.07%
    UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research.
  • HY-110079
    TNP
    		Inhibitor 99.29%
    TNP is a competitive, reversible inhibitor of IP6K1 and IP3K, with IC50s of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP competitively binds to the ATP binding site of IP6K, inhibits the generation of 5-IP7, and thus relieves the inhibition of 5-IP7 on the AKT signaling pathway. TNP can enhance insulin sensitivity and promote thermogenesis in adipose tissue. TNP cannot effectively pass through the blood-brain barrier and is mainly used in the study of obesity, type 2 diabetes, and metabolic syndrome. However, TNP also inhibits CYP3A4 and may need further optimization[1][2][3].
  • HY-153530
    LI-2242
    		Inhibitor 98.95%
    LI-2242 is an inositol hexakisphosphate kinase (IP6K) inhibitor. LI-2242 has inhibition effect for IP6K1, IP6K2, IP6K3 and IPMK with IC50 values of 31 nM, 42 nM, 8.7 nM and 1944 nM, respectively. LI-2242 can be used for thew research of type II diabetes, obesity, metabolic complications, venous thrombosis, and psychiatric disorders.
  • HY-122706A
    IP6K2-IN-2
    		Inhibitor 98.85%
    IP6K2-IN-2 (Compound 6) is an IP6K2 inhibitor, with IC50 values of 0.58 μM (IP6K2), 0.86 μM (IP6K1) and 3.08 μM (IP6K3). IP6K2-IN-2 can be used in research of obesity.
  • HY-162016
    IP6K-IN-1
    		Inhibitor
    IP6K-IN-1 (compound 24) is a potent and selective inhibitor of IP6K with an IC50 of 0.896 μM. IP6K-IN-1 can used in study metabolic disease.
  • HY-162821
    LI-3948
    		Inhibitor
    IP6K-IN-2 (compound 29c) is an orally bioavailable and blood-brain barrier permeable IP6K inhibitor (IC50: 15.8 nM) that can be used in the study of central nervous system diseases.
  • HY-161032
    IP6K2-IN-1
    		Inhibitor
    IP6K2-IN-1 (Compd 20s) is a selective IP6K2 inhibitor, with an ICIC50 value of 0.55 μM.