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UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research.

For research use only. We do not sell to patients.

UNC7467 Chemical Structure

UNC7467 Chemical Structure

CAS No. : 2922283-43-8

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Based on 1 publication(s) in Google Scholar

UNC7467 Related Antibodies

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  • Purity & Documentation

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Description

UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research[1].

IC50 & Target

IC50: 4.9 nM (IP6K2), 8.9 nM (IP6K1), 1320 nM (IP6K3)[1].
Cellular Effect
Cell Line Type Value Description References
HCT-116 EC50
0.24 μM
Compound: 20; UNC7467
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 18 hrs by HPLC analysis
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 18 hrs by HPLC analysis
[PMID: 35467861]
HCT-116 EC50
1 μM
Compound: 20; UNC7467
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 3 hrs by HPLC analysis
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 3 hrs by HPLC analysis
[PMID: 35467861]
In Vitro

UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces levels of inositol pyrophosphates. UNC7467 reduces 5-InsP7 levels by 81% and 5-InsP8 levels by 63%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UNC7467 Related Antibodies
In Vivo

UNC7467 (5 mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) ameliorated diet induced obesity, insulin resistance, and hepatic steatosis[1].
UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUClast (6054 h•ng/mL for intra venous (i.v.) and 2527 h•ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obesity (DIO) mice[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; daily, for 4 weeks
Result: Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake.
Animal Model: Diet-induced obesity (DIO) mice[1]
Dosage: 5 mg/kg (Pharmacokinetic Analysis)
Administration: Intravenous injection and intraperitoneal injection
Result: 1.19
route iv ip
Dose (mg/kg) 5 5
AUClast (h*ng/mL) 6054 2527
CL (mL/min/kg) 13.7
Molecular Weight

315.32

Formula

C20H13NO3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC2=C(ON=C2C=C1)C3=CC=C(C=C3)C4=CC=CC=C4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (45.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1714 mL 15.8569 mL 31.7138 mL
5 mM 0.6343 mL 3.1714 mL 6.3428 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1714 mL 15.8569 mL 31.7138 mL 79.2845 mL
5 mM 0.6343 mL 3.1714 mL 6.3428 mL 15.8569 mL
10 mM 0.3171 mL 1.5857 mL 3.1714 mL 7.9285 mL
15 mM 0.2114 mL 1.0571 mL 2.1143 mL 5.2856 mL
20 mM 0.1586 mL 0.7928 mL 1.5857 mL 3.9642 mL
25 mM 0.1269 mL 0.6343 mL 1.2686 mL 3.1714 mL
30 mM 0.1057 mL 0.5286 mL 1.0571 mL 2.6428 mL
40 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
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UNC7467 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC74672922283-43-8UNC 7467UNC-7467OthersIP6Kinositol pyrophosphatesobesityInhibitorinhibitorinhibit

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