2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. KMO
  5. KMO Inhibitor

KMO Inhibitor

KMO Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-12347
    Ro 61-8048
    		Inhibitor 99.76%
    Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations.
  • HY-112179
    GSK180
    		Inhibitor 99.04%
    GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition.
  • HY-15500
    JM6
    		Inhibitor
    JM6 is a weak kynurenine 3-monooxygenase (KMO) inhibitor with an IC50 of 19.85 μM for mouse KMO. JM6 can be used for Alzheimer's diseases research.