2. Signaling Pathways
  3. Immunology/Inflammation
  4. LAG-3

LAG-3

Lymphocyte activation gene-3; CD223

Lymphocyte activation gene-3 (LAG-3) is an immune checkpoint protein that belongs to the immunoglobulin superfamily. LAG-3 is mainly expressed on activated T cells, NK cells, B cells and plasmacytoid dendritic cells. LAG-3 has a high affinity for MHC class II molecules and can also bind to FGL1. Binding of LAG-3 to its ligands leads to the inhibition of T cell activation and proliferation, thereby regulating the immune response. In the tumor microenvironment, overexpression of LAG-3 is often observed, which helps tumor cells escape immune surveillance. LAG-3 is considered as an important target for cancer immunotherapy. In addition to its role in tumor immunity, LAG-3 is also involved in the pathogenesis of some autoimmune diseases and infectious diseases[1][2][3].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P990740
    Fanastomig
    Fanastomig is an anti-PDCD1/LAG3 monoclonal antibody.
    Fanastomig
  • HY-P990204
    Anti-Mouse LAG-3 (D265A) Antibody (C9B7W)
    		Inhibitor
    Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse LAG-3.
    Anti-Mouse LAG-3 (D265A) Antibody (C9B7W)
  • HY-P990750
    Negalstobart
    Negalstobart is an anti-LAG3 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Negalstobart
  • HY-P990195
    Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8)
    		Inhibitor
    Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse MHC Class I.
    Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8)
  • HY-164308
    SA-15-P
    		Inhibitor
    SA-15-P inhibits LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies.
    SA-15-P
  • HY-P991096
    EMB-02
    		Inhibitor
    EMB-02 is a bispecific PD-1 and LAG-3 antibody. EMB-02 inhibits the PD-1- and LAG-3-mediated downregulation of T-cell activation and proliferation. EMB-02 has a potent anticancer effects.
    EMB-02
Cat. No. Product Name / Synonyms Application Reactivity