mAChR

Muscarinic acetylcholine receptor

mAChR

mAChR Isoform Specific Products:

mAChR Isoform Comparison

mAChR Related Products (563)
Antibodies (2)
mAChR Isoform Comparison

By Effects:	Controls (6) Inhibitors (97) Ligand (1) Agonists (111) Antagonists (271) Activators (10) Modulators (32) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-17366

Clozapine N-oxide	Agonist	99.98%
Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist.

HY-42110

Deschloroclozapine	Agonist	99.83%
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with K_i of 6.3 and 4.2 nM, respectively. [¹¹C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.

HY-B0726

Pilocarpine Hydrochloride	Agonist	99.98%
Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-17366A

Clozapine N-oxide dihydrochloride	Agonist	99.74%
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist.

HY-B0726A

Pilocarpine	Agonist	99.89%
Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-17585

Mepenzolate bromide	Antagonist	99.90%
Mepenzolate bromide is an orally administered muscarinic receptor antagonist with K_is of 0.68 and 2.6 nM for hM2R and hM3R, respectively. Mepenzolate bromide can be used to suppress the gastrointestinal hypermotility associated with irritable bowel syndrome.Mepenzolate bromide is a GPR109A inhibitor.

HY-N2364

Arecoline	Antagonist	99.84%
Arecoline, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline also can induce oxidative stress.

HY-B0489

Arecoline hydrobromide	Agonist	99.95%
Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress.

HY-14539

Clozapine	Modulator	99.84%
Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K_i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K_is of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC₅₀=11 nM).

HY-14541

Olanzapine	Antagonist	99.37%
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic.

HY-105182

Xanomeline	Agonist	99.52%
Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia.

HY-A0083

Methacholine chloride	Agonist	≥98.0%
Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates.

HY-B0527A

Amitriptyline hydrochloride	Inhibitor	98.91%
Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.

HY-42110A

Deschloroclozapine dihydrochloride	Agonist	99.87%
Deschloroclozapine dihydrochloride, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with K_i of 6.3 and 4.2 nM, respectively. [¹¹C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.

HY-N0110

Palmatine chloride		99.81%
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.

HY-107647

(S)-(+)-Dimethindene maleate	Antagonist	99.94%
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M₂-selective muscarinic receptor antagonist (pA₂ = 7.86/7.74; pK_i = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M₁ (pA₂ = 6.83/6.36; pK_i = 7.08), the M₃ (pA₂ = 6.92/6.96; pK_i = 6.70) and the M₄ receptors (pK_i = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H₁ receptor antagonist (pA₂ = 7.48).

HY-A0012

Darifenacin hydrobromide	Antagonist	99.97%
Darifenacin (UK-88525) hydrobromide is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin hydrobromide binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin hydrobromide can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin hydrobromide inhibits tumor growth in colorectal cancer cells and has anti-tumor effects.

HY-B1188

Propantheline bromide	Antagonist
Propantheline bromide is an orally active mAChR antagonist. Propantheline bromide can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination.

HY-105182A

Xanomeline tartrate	Agonist	99.93%
Xanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia.

HY-B1205A

Atropine sulfate	Antagonist	99.74%
Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia.

Clozapine N-oxide			mAChR3	mAChR4		99.98%
Deschloroclozapine			mAChR3	mAChR4		99.83%
Pilocarpine Hydrochloride			mAChR3			99.98%
Clozapine N-oxide dihydrochloride			mAChR3	mAChR4		99.74%
Pilocarpine			mAChR3			99.89%
Clozapine	mAChR1, Ki: 9.5 nM (Antagonist)			mAChR4, EC₅₀: 11 nM (Agonist)		99.84%
Xanomeline	mAChR1			mAChR4		99.52%
Methacholine chloride			mAChR3			≥98.0%
(S)-(+)-Dimethindene maleate	mAChR1, pKi: 7.08	mAChR2, pKi: 7.78	mAChR3, pKi: 6.70	mAChR4, pKi: 7.00		99.94%
Darifenacin hydrobromide			mAChR3			99.97%
Atropine sulfate				mAChR4		99.74%
DREADD agonist 21			mAChR3			99.46%
Iperoxo	mAChR1, pEC₅₀: 9.87	mAChR2, pEC₅₀: 10.1	mAChR3, pEC₅₀: 9.78			99.48%
Oxotremorine sesquifumarate		mAChR2				≥98.0%
4-DAMP			mAChR3		mAChR5	99.99%
Trospium chloride	mAChR1	mAChR2	mAChR3			99.88%
Atropine sulfate monohydrate				mAChR4		99.68%
Pirenzepine dihydrochloride	mAChR1					99.84%
Bethanechol chloride	mAChR1		mAChR3	mAChR4	mAChR5	98.15%
DREADD agonist 21 dihydrochloride			mAChR3			98.94%
Tropicamide				mAChR4		99.22%
VU 0255035	mAChR1					99.76%
Fesoterodine fumarate	mAChR1		mAChR3	mAChR4	mAChR5	99.73%
VU0467154				mAChR4		99.56%
Diphenidol hydrochloride	mAChR1	mAChR2	mAChR3	mAChR4		99.95%
Pilocarpine nitrate			mAChR3			99.83%
Cevimeline hydrochloride hemihydrate	mAChR1		mAChR3			99.52%
Ipratropium bromide	mAChR1	mAChR2	mAChR3			99.92%
Cevimeline hydrochloride	mAChR1		mAChR3			98.74%
Darifenacin			mAChR3			99.81%
Dicyclomine hydrochloride	mAChR1	mAChR2				≥98.0%
(Rac)-5-Hydroxymethyl Tolterodine	mAChR1		mAChR3	mAChR4	mAChR5	99.59%
N-Desmethylclozapine	mAChR1					98.99%
Telenzepine dihydrochloride	mAChR1					99.08%
Otenzepad		mAChR2				99.93%
VU 0238429					mAChR5	99.96%
VU0357017 hydrochloride	mAChR1					99.91%
Aceclidine	mAChR1		mAChR3			99.23%
Smilagenin	mAChR1					≥98.0%
Fesoterodine L-mandelate	mAChR1		mAChR3	mAChR4	mAChR5	99.00%
VU6028418				mAChR4		99.52%
Imidafenacin			mAChR3			99.32%
VU0152100				mAChR4		98.98%
Solifenacin	mAChR1	mAChR2	mAChR3			99.83%
VU6019650					mAChR5, IC₅₀: 36 nM	98.61%
Biperiden hydrochloride	mAChR1					99.90%
Umeclidinium bromide	mAChR1				mAChR5	99.72%
Trihexyphenidyl hydrochloride	mAChR1					99.93%
McN-A-343	mAChR1					99.77%
VU 6008667					mAChR5	99.53%
Penehyclidine hydrochloride	mAChR1		mAChR3			99.2%
Sofpironium bromide			mAChR3	mAChR4	mAChR5	98.26%
PD 102807				mAChR4		98.52%
Ipratropium bromide hydrate	mAChR1, IC₅₀: 2.9 nM	mAChR2, IC₅₀: 2 nM	mAChR3, IC₅₀: 1.7 nM			99.90%
Batefenterol		mAChR2	mAChR3			98.30%
Talsaclidine		mAChR2	mAChR3			≥98.0%
VU0364572 TFA	mAChR1, EC₅₀: 0.11 μM					99.27%
TBPB	mAChR1, EC₅₀: 289 nM					99.74%
ML375					mAChR5	99.70%
ASP8302			mAChR3			98.95%
Olanzapine-d₃	mAChR1					99.09%
LY2119620		mAChR2		mAChR4		99.74%
VU 0365114					mAChR5	99.41%
Clozapine (Standard)	mAChR1			mAChR4		99.98%
PCS1055 dihydrochloride				mAChR4		98.88%
Fesoterodine	mAChR1		mAChR3	mAChR4	mAChR5	99.02%
Tarafenacin D-tartrate			mAChR3			99.86%
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride	mAChR1		mAChR3	mAChR4	mAChR5
AC260584	mAChR1					99.60%
VU6004256	mAChR1, EC₅₀: 155 nM					99.61%
HY-078020			mAChR3			98.87%
Solifenacin hydrochloride	mAChR1	mAChR2	mAChR3			99.71%
PCS1055				mAChR4, IC₅₀: 18.1 nM mAChR4, Kd: 5.72 nM		98.02%
VU10010				mAChR4		98.70%
mAChR antagonist 1	mAChR1, Ki: 255 nM	mAChR2, Ki: >1000 nM	mAChR3, Ki: 121 nM	mAChR4, Ki: 158 nM	mAChR5, Ki: 255 nM	99.59%
p-F-HHSiD hydrochloride			mAChR3
PDE4-IN-4			mAChR3
VLVNTFCDSCIPKTYWNLGY TFA			mAChR3
VU0448088				mAChR4, EC₅₀: 56 nM		98.67%
Bethanechol	mAChR1		mAChR3	mAChR4	mAChR5
Tarafenacin			mAChR3
YM-58790	mAChR1, Ki: 28 nM	mAChR2, Ki: 260 nM	mAChR3, Ki: 15 nM			98.21%
Cevimeline	mAChR1		mAChR3
(Rac)-VU 6008667					mAChR5	99.85%
Penehyclidine	mAChR1		mAChR3
rel-Biperiden EP impurity A-d₅	mAChR1
Solifenacin D5 hydrochloride	mAChR1	mAChR2	mAChR3
M1/M4 muscarinic agonist 1	mAChR1, EC₅₀: 55 nM			mAChR4, EC₅₀: 14 nM
N-Desmethylclozapine-d₈	mAChR1
Pilocarpine-d₃ hydrochloride			mAChR3
Solifenacin-d₅ succinate	mAChR1	mAChR2	mAChR3
YM-58790 free base	mAChR1, Ki: 28 nM	mAChR2, Ki: 260 nM	mAChR3, Ki: 15 nM
Pirenzepine-d₈	mAChR1
PTAC oxalate	mAChR1, Ki: 0.6 nM	mAChR2, Ki: 2.8 nM	mAChR3, Ki: 0.2 nM	mAChR4, Ki: 0.2 nM	mAChR5, Ki: 0.8 nM
(±)-Darifenacin-d₄ hydrobromide			mAChR3
LAS190792	mAChR1, pIC₅₀: 8.9	mAChR2, pIC₅₀: 8.8	mAChR3, pIC₅₀: 8.8	mAChR4, pIC₅₀: 9.2	mAChR5, pIC₅₀: 8.2
DIBA-Cy5	mAChR1, Kd: 104.5 nM	mAChR2, Kd: 1.80 nM
Atropine hydrobromide				mAChR4
M4 mAChR Modulator-1				mAChR4
Lu 26-046	mAChR1, Ki: 0.51 nM	mAChR2, Ki: 26 nM	mAChR3, Ki: 5 nM
5-Hydroxymethyl Tolterodine-d₁₄ formate	mAChR1		mAChR3	mAChR4	mAChR5
M1 ligand 1	mAChR1
J 104129 fumarate		mAChR2, Ki: 490 nM	mAChR3, Ki: 4.2 nM
Umeclidinium-d₅ bromide	mAChR1				mAChR5
rel-Biperiden EP impurity B-d₅	mAChR1
Hexocyclium methylsulfate	mAChR1, pKi: 8.9	mAChR2, pKi: 7.7	mAChR3, pKi: 8.4	mAChR4, pKi: 8.8
Diphenidol	mAChR1	mAChR2	mAChR3	mAChR4
Dicyclomine	mAChR1	mAChR2
Solifenacin-d₇ hydrochloride	mAChR1	mAChR2	mAChR3
Biperiden-d₅ hydrochloride	mAChR1
Clozapine dihydrochloride	mAChR1, Ki: 9.5 nM			mAChR4, EC₅₀: 11 nM
(±)-Darifenacin-d₄			mAChR3
Umeclidinium-d₁₀ bromide	mAChR1				mAChR5
MHP 133	mAChR1	mAChR2
M1/M2/M4 muscarinic agonist 1	mAChR1, EC₅₀: 26 nM	mAChR2, EC₅₀: 210 nM		mAChR4, EC₅₀: 6.5 nM
Aceclidine hydrochloride	mAChR1		mAChR3			≥98.0%
CHF-6550			mAChR3, pKi: 9.3
Darifenacin (hydrobromide) (Standard)			mAChR3
TAAR1 agonist 2		mAChR2, pEC₅₀: 5
rel-Biperiden-d₅	mAChR1
Direclidine				mAChR4
Sofpironium tosylate	mAChR1	mAChR2	mAChR3	mAChR4	mAChR5
Trihexyphenidyl-d₅ hydrochloride	mAChR1
PF-3635659			mAChR3
AE9C90CB	mAChR1, pKi: 9.7	mAChR2, pKi: 8.6	mAChR3, pKi: 9.9	mAChR4, pKi: 9.5	mAChR5, pKi: 9.5
Alvameline			mAChR3
Revatropate	mAChR1	mAChR2	mAChR3
Atropine oxide hydrochloride	mAChR1	mAChR2	mAChR3	mAChR4	mAChR5
Rispenzepine	mAChR1		mAChR3
(1R,3S-)Solifenacin-d₅ hydrochloride	mAChR1	mAChR2	mAChR3
Clozapine hydrochloride	mAChR1, Ki: 9.5 nM			mAChR4, EC₅₀: 11 nM

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mAChR

mAChR

mAChR Isoform Specific Products:

mAChR Isoform Specific Products:

mAChR Related Products (563)

Antibodies (2)

mAChR Isoform Comparison

mAChR Related Products (563):