2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mAChR

mAChR

Muscarinic acetylcholine receptor

mAChR

Related Products

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mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Isoform Specific Products:

mAChR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-107650A
    Milameline hydroiodide
    		Agonist
    Milameline (CI 979) hydroiodide is a muscarinic receptor agonist that improves cognition.
    Milameline hydroiodide
  • HY-15851R
    Revefenacin (Standard)
    		Antagonist
    Revefenacin (Standard) is the analytical standard of Revefenacin. This product is intended for research and analytical applications. Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM.
    Revefenacin (Standard)
  • HY-101586A
    Alvameline maleate
    		Antagonist
    Alvameline (Lu 25-109) maleate is a partial agonist of M1 and an antagonist of M2/M3. Alvameline maleate competitively antagonizes contractions induced by ammonium chloride (HY-Y1269) and electrical field stimulation in human detrusor muscle, indicating its potential application in regulating bladder function. Additionally, alvameline maleate can improve cognitive function following traumatic brain injury in rats.
    Alvameline maleate
  • HY-12100R
    Umeclidinium (bromide) (Standard)
    		Antagonist
    Umeclidinium (bromide) (Standard) is the analytical standard of Umeclidinium (bromide). This product is intended for research and analytical applications. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.
    Umeclidinium (bromide) (Standard)
  • HY-101368A
    WIN 64338 hydrochloride
    		Antagonist
    WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a Ki of 64 nM. WIN 64338 hydrochloride also can inhibits [3H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (Ki=350 nM).
    WIN 64338 hydrochloride
  • HY-112076R
    Atropine methyl (bromide) (Standard)
    		Antagonist
    Atropine methyl (bromide) (Standard) is the analytical standard of Atropine methyl (bromide). This product is intended for research and analytical applications. Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine.
    Atropine methyl (bromide) (Standard)
  • HY-U00055
    Temiverine hydrochloride
    		Antagonist
    Temiverine hydrochloride is a synthesized agent that is expected to have anticholinergic action. Temiverine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Temiverine hydrochloride
  • HY-U00067
    Ambutonium bromide
    		Antagonist
    Ambutonium bromide is an acetylcholine antagonist.
    Ambutonium bromide
  • HY-U00038
    ENS-163 phosphate
    		Agonist
    ENS-163 phosphate is a selective muscarinic M1 receptor agonist.
    ENS-163 phosphate
  • HY-U00030
    Rispenzepine
    		Antagonist
    Rispenzepine is a novel antimuscarinic compound with a preferential action at M1, and M3 receptor subtypes.
    Rispenzepine
  • HY-101694
    Siltenzepine
    		Antagonist
    Siltenzepine (AWD 26-06 free base) is an antagonist of mAChR with anti-acid activity, which can be used in peptic ulcers research. Siltenzepine exhibits rapidly but incompletely absorbed characterastic in rats (po).
    Siltenzepine
  • HY-101743
    Elucaine
    		Antagonist
    Elucaine is a muscarinic acetylcholine receptor antagonist with anti-ulcerative activity.
    Elucaine
  • HY-A0034R
    Solifenacin (Standard)
    		Antagonist
    Solifenacin (Standard) is the analytical standard of Solifenacin. This product is intended for research and analytical applications. Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
    Solifenacin (Standard)
  • HY-121404B
    Muscarine tosylate
    		Agonist
    Muscarine ((+)-Muscarine) tosylate is an agonist of prototype mAChR. Muscarine tosylate is a toxin that can stimulate the parasympathetic nervous system.
    Muscarine tosylate
  • HY-119953
    BIBN-99
    		Antagonist
    BIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury.
    BIBN-99
  • HY-B0662A
    Imidafenacin hydrochloride
    		Inhibitor
    Imidafenacin hydrochloride is a potent and selective inhibitor of M3 receptors with a Kb of 0.317 nM.
    Imidafenacin hydrochloride
  • HY-14539S3
    Clozapine-d3
    		Modulator
    Clozapine-d3 (HF 1854-d3) is deuterium labeled Clozapine. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).
    Clozapine-d<sub>3</sub>
  • HY-19652A
    (S)-Oxybutynin hydrochloride
    		Antagonist
    (S)-Oxybutynin (Esoxybutynin) hydrochloride is a potent muscarinic receptor antagonist.
    (S)-Oxybutynin hydrochloride
  • HY-N7247R
    Thiochrome (Standard)
    		Activator
    Thiochrome (Standard) is the analytical standard of Thiochrome. This product is intended for research and analytical applications. Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors.
    Thiochrome (Standard)
  • HY-17465R
    Glycopyrrolate (Standard)
    		Antagonist
    Glycopyrrolate (Standard) is the analytical standard of Glycopyrrolate. This product is intended for research and analytical applications. Glycopyrrolate (Glycopyrronium bromide), a quaternary ammonium derivative, is a muscarinic receptor antagonist. Glycopyrrolate has bronchoprotective effect and produces a beneficial effect on blood pressure. Glycopyrrolate can be used for the research of bronchial diseases.
    Glycopyrrolate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
mAChR Isoform Comparison

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