2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mAChR

mAChR

Muscarinic acetylcholine receptor

mAChR

Related Products

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mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Isoform Specific Products:

mAChR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13204AR
    Biperiden (Standard)
    		Inhibitor
    Biperiden (Standard) is the analytical standard of Biperiden. This product is intended for research and analytical applications. Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.
    Biperiden (Standard)
  • HY-43421
    Solifenacin N-oxide
    		Control
    Solifenacin N-oxide (Solifenacin N1-oxide) is an inactive metabolite of the muscarinic receptor antagonist Solifenacin (HY-A0034).
    Solifenacin N-oxide
  • HY-135329S
    (1R,3S-)Solifenacin-d5 hydrochloride
    		Antagonist
    (1R,3S-)Solifenacin-d5 (hydrochloride) is the deuterium labeled Solifenacin D5 hydrochloride. Solifenacin D5 hydrochloride is a deuterium labeled Solifenacin hydrochloride. Solifenacin hydrochloride is a muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively[1].
    (1R,3S-)Solifenacin-d<sub>5</sub> hydrochloride
  • HY-B0267R
    Oxybutynin (Standard)
    		Antagonist
    Oxybutynin (Standard) is the analytical standard of Oxybutynin. This product is intended for research and analytical applications. Oxybutynin is an anticholinergic agent, which inhibits vascular Kv channels in a concentration-dependent manner, with an IC50 of 11.51 μM. Oxybutynin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Oxybutynin (Standard)
  • HY-B0726R
    Pilocarpine Hydrochloride (Standard)
    		Agonist
    Pilocarpine (Hydrochloride) (Standard) is the analytical standard of Pilocarpine (Hydrochloride). This product is intended for research and analytical applications. Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
    Pilocarpine Hydrochloride (Standard)
  • HY-W739521
    N-Desethyloxybutynin hydrochloride
    		Modulator
    N-Desethyloxybutynin hydrochloride is an active metabolite of Oxybutynin. N-Desethyloxybutynin hydrochloride binds to mAChRs in isolated? human bladder and human parotid gland with pKi values of 8.2 and 8.7, respectively.
    N-Desethyloxybutynin hydrochloride
  • HY-U00001A
    Phenglutarimid hydrochloride
    		Inhibitor
    Phenglutarimid hydrochloride is an anticholinergic used as an antiparkinsonian agent.
    Phenglutarimid hydrochloride
  • HY-76569S1
    (R)-Hydroxytolterodine-d14
    		Antagonist
    (R)-Hydroxytolterodine-d14 is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively. Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053). Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats.
    (R)-Hydroxytolterodine-d<sub>14</sub>
  • HY-118356
    WIN 62,577
    		Antagonist
    WIN 62,577 is a rat-specific, but non-human, NK1 receptor antagonist. WIN 62,577 interacts with M1-M4 mAChRs and is an allosteric enhancer of acetylcholine affinity targeting the M3 receptor.
    WIN 62,577
  • HY-14539A
    Clozapine hydrochloride
    		Modulator
    Clozapine hydrochloride (HF 1854 hydrochloride) is an antipsychotic used for the research of schizophrenia. Clozapine hydrochloride has high affinity for a number of neuroreceptors. Clozapine hydrochloride is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine hydrochloride inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine hydrochloride is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).
    Clozapine hydrochloride
  • HY-B1339R
    Dicyclomine (hydrochloride) (Standard)
    		Inhibitor
    Dicyclomine (hydrochloride) (Standard) is the analytical standard of Dicyclomine (hydrochloride). This product is intended for research and analytical applications. Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo.
    Dicyclomine (hydrochloride) (Standard)
  • HY-B1132R
    Clidinium (bromide) (Standard)
    		Antagonist
    Clidinium (bromide) (Standard) is the analytical standard of Clidinium (bromide). This product is intended for research and analytical applications. Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo.
    Clidinium (bromide) (Standard)
  • HY-116490
    Guvacoline hydrobromide
    		Agonist
    Guvacoline hydrobromide, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal mAChR.
    Guvacoline hydrobromide
  • HY-A0016S
    Dronedarone-d6 hydrochloride
    		Inhibitor
    Dronedarone-d6 (hydrochloride) is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4[1][2][3][4].
    Dronedarone-d<sub>6</sub> hydrochloride
  • HY-U00139
    Cyclodrine hydrochloride
    		Antagonist
    Cyclodrine hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist.
    Cyclodrine hydrochloride
  • HY-U00230
    CDD0102
    		Agonist
    CDD0102 is a potent M1 Muscarinic receptor agonist.
    CDD0102
  • HY-U00203
    Tematropium
    		Inhibitor 98.12%
    Tematropium (CDDD3602) is a soft anticholinergics.
    Tematropium
  • HY-U00406
    BTM-1086
    		Modulator
    BTM-1086 is a potent anti-ulcer and gastric secretory inhibiting agent.
    BTM-1086
  • HY-U00104
    YM-46303
    		Antagonist
    YM-46303 is an mAChR antagonist which exhibits the highest affinities for M1 and M3 receptors, and selectivity for M3 over M2 receptor.
    YM-46303
  • HY-U00415
    Benzamide Derivative 1
    		Antagonist
    Benzamide Derivative 1 is a benzamide derivative from patent EP0213775A1, compound 18. Benzamide Derivative 1 may be useful in treatment of gastrointestinal disorders.
    Benzamide Derivative 1
Cat. No. Product Name / Synonyms Application Reactivity
mAChR Isoform Comparison

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