2. Signaling Pathways
  3. GPCR/G Protein
  4. Mas-related G-protein-coupled Receptor (MRGPR)
  5. Mas-related G-protein-coupled Receptor (MRGPR) Antagonist

Mas-related G-protein-coupled Receptor (MRGPR) Antagonist

Mas-related G-protein-coupled Receptor (MRGPR) Antagonists (8):

Cat. No. Product Name Effect Purity
  • HY-146220
    MrgprX2 antagonist-8
    		Antagonist
    MrgprX2 antagonist-8 (example 5b) is a MrgprX2 antagonist. MrgprX2 antagonist-8 can be used for the research of inflammatory disorders.
  • HY-156907
    ZINC49534341
    		Antagonist 99.13%
    ZINC49534341 is a MRGPRX2 antagonist, with a Ki of 32 nM.
  • HY-145893
    MrgprX2 antagonist-7
    		Antagonist
    MrgprX2 antagonist-7 (compound 10) is an anti-allergic agent. MrgprX2 antagonist-7 shows excellent anti-allergy effects and can inhibit mast cell degranulation.
  • HY-145892
    MrgprX2 antagonist-6
    		Antagonist
    MrgprX2 antagonist-6 (compound 9) is an anti-allergic agent. MrgprX2 antagonist-6 shows excellent anti-allergy effects and can inhibit mast cell degranulation.
  • HY-148492
    Mrgx2 antagonist-2
    		Antagonist
    Mrgx2 antagonist-2 is a Mrgx2 antagonist (Example 123 in reference patent) with a pIC50 of 8.6. Mrgx2 antagonist-2 can be used in the research of MrgX2 -mediated diseases or disorders.
  • HY-147106
    Mrgx2 antagonist-1
    		Antagonist
    Mrgx2 antagonist-1 (example 1) is a potent Mrgx2 (Mas-related Gene X2) antagonist. Mrgx2 antagonist-1 can be used for the research of MrgX2-mediated diseases and disorders.
  • HY-145193A
    (R)-MrgprX2 antagonist-3
    		Antagonist
    (R)-MrgprX2 antagonist-3 (compound E118) is an MrgprX2 antagonist extracted from patent WO2021092240A1, example E118. (R)-MrgprX2 antagonist-3 can be used for the research of inflammatory disorders of the skin.
  • HY-111273
    AR244555
    		Antagonist
    AR244555 is a malate-aspartate shuttle (MAS) inverse agonist with IC50s of 186 nM and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively. AR244555 has cardioprotective effects.