2. GPCR/G Protein
  3. Mas-related G-protein-coupled Receptor (MRGPR)
  4. MrgprX2 antagonist-8

MrgprX2 antagonist-8 (example 5b) is a MrgprX2 antagonist. MrgprX2 antagonist-8 can be used for the research of inflammatory disorders.

For research use only. We do not sell to patients.

MrgprX2 antagonist-8 Chemical Structure

MrgprX2 antagonist-8 Chemical Structure

CAS No. : 2768216-96-0

Size Price Stock Quantity
1 mg USD 130 In-stock
5 mg USD 320 In-stock
10 mg USD 460 In-stock
25 mg USD 750 In-stock
50 mg USD 990 In-stock
100 mg USD 1350 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

MrgprX2 antagonist-8 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MrgprX2 antagonist-8 (example 5b) is a MrgprX2 antagonist. MrgprX2 antagonist-8 can be used for the research of inflammatory disorders[1].

IC50 & Target

IC50 & target: MrgprX2[1]
In Vitro

MrgprX2 antagonist-8 has an activity of 100-500 nM in the hexokinase assay using LAD2 mast cells[1].
MrgprX2 antagonist-8 has an activity of less than 100 nM in CHO cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MrgprX2 antagonist-8 Related Antibodies
Molecular Weight

540.99

Formula

C24H24ClF3N4O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H]1CC[C@@H](NC2=CC(C(F)(F)F)=NC3=CC=C(Cl)C=C23)CC1)C4=CC=CC(NS(=O)(C)=O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (462.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8485 mL 9.2423 mL 18.4846 mL
5 mM 0.3697 mL 1.8485 mL 3.6969 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8485 mL 9.2423 mL 18.4846 mL 46.2116 mL
5 mM 0.3697 mL 1.8485 mL 3.6969 mL 9.2423 mL
10 mM 0.1848 mL 0.9242 mL 1.8485 mL 4.6212 mL
15 mM 0.1232 mL 0.6162 mL 1.2323 mL 3.0808 mL
20 mM 0.0924 mL 0.4621 mL 0.9242 mL 2.3106 mL
25 mM 0.0739 mL 0.3697 mL 0.7394 mL 1.8485 mL
30 mM 0.0616 mL 0.3081 mL 0.6162 mL 1.5404 mL
40 mM 0.0462 mL 0.2311 mL 0.4621 mL 1.1553 mL
50 mM 0.0370 mL 0.1848 mL 0.3697 mL 0.9242 mL
60 mM 0.0308 mL 0.1540 mL 0.3081 mL 0.7702 mL
80 mM 0.0231 mL 0.1155 mL 0.2311 mL 0.5776 mL
100 mM 0.0185 mL 0.0924 mL 0.1848 mL 0.4621 mL
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MrgprX2 antagonist-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MrgprX2 antagonist-82768216-96-0Mas-related G-protein-coupled Receptor (MRGPR)inflammatory disordersInhibitorinhibitorinhibit

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