Methionine Adenosyltransferase (MAT)

S-adenosylmethionine Synthetase

Methionine adenosyltransferases (MATs), also known as S-Adenosylmethionine synthetase, are essential enzymes for life as they catalyzes the synthesis of one of the most important and pivotal biological molecules, S-adenosyl-methionine. S-adenosyl-methionine is the biological methyl donor required for a plethora of reactions within the cell.Mammalian systems express two genes, MAT1A and MAT2A, which encode for MATα1 and MATα2, the catalytic subunits of the MAT isoenzymes, respectively. A third gene MAT2B, encodes a regulatory subunit known as MATβ which controls the activity of MATα2. MAT1A, which is mainly expressed in hepatocytes, maintains the differentiated state of these cells, whilst MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal cells of the liver (e.g., hepatic stellate and Kupffer cells).

Methionine Adenosyltransferase (MAT) Inhibitors (24)

Methionine Adenosyltransferase (MAT) Related Products (32):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-168445

MAT2A-IN-21	Inhibitor
MAT2A-IN-21 (compound 28) is a potent methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC₅₀ of 49 nM. MAT2A-IN-21 selectivity inhibits MTAP-deficient cancer cells.

HY-170502

MAT2A-IN-19	Inhibitor
MAT2A-IN-19 (Compound I-3) is an inhibitor for methionine adenosyltransferase 2A (MAT2A) with an IC₅₀ of 32.93 nM.

HY-162010

MAT2A-IN-13	Inhibitor
MAT2A-IN-13 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with a favorable pharmacokinetic profile. MAT2A-IN-13 shows in vivo potency in an HCT-116 MTAP-deleted xenograft model. MAT2A-IN-13 can be used for MTAP-Deleted tumors treatment research.

HY-144181

MAT2A-IN-5	Inhibitor
MAT2A-IN-5 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally elevated in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-5 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-5 has the potential for the potential for the research of cancer diseases (extracted from patent WO2021254529A1, compound 1).

HY-155149

MAT2A-IN-12	Inhibitor
MAT2A Allosteric inhibitor 2 is a potent and selective MAT2A allosteric inhibitor with an IC₅₀ of 5 nM. MAT2A Allosteric inhibitor 2 shows nanomolar activity (IC₅₀=5 μM) in the the proliferation assay (MTAP^-/- cell line).

HY-155148

MAT2A-IN-11	Inhibitor
MAT2A Allosteric inhibitor 1 (compound 5) is a MAT2A selective inhibitor of methionine adenosyltransferase (MAT) with an IC₅₀ of 6.8 nM.

HY-161298

MAT2A-IN-15	Inhibitor
MAT2A-IN-15 (compound 8) is an inhibitor of MAT2A.

HY-159156

MAT2A inhibitor 6	Inhibitor
MAT2A inhibitor 6 (Compound 3N-h) is a specific MAT2A inhibitor with oral activity and yellow fluorescence (IC₅₀=26 nM), capable of visualizing MAT2A both in vitro and in vivo (λex = 430 nm, λem = 585 nm). MAT2A inhibitor 6 can induce apoptosis and has anticancer activity, which can be used in cancer research.

HY-149915

MAT2A-IN-10	Inhibitor
MAT2A-IN-10 (Compound 28) is an orally active MAT2A inhibitor with an IC₅₀ of 26 nM. MAT2A-IN-10 can be used for the research of cancer.

HY-144179

MAT2A-IN-4	Inhibitor
MAT2A-IN-4 is a methionine adenosyltransferase 2A (MAT2A) inhibitor extracted from patent WO2020123395A1 compound 426 . MAT2A-IN-4 can be used for the research of cancer.

HY-163656

MAT2A inhibitor 5	Inhibitor
MAT2A inhibitor 5(compound 39) is an orally active, selectivity and blood-brain permeability inhibitor of MAT2A with the IC₅₀ of 11 nM. MAT2A inhibitor 5 inhibits tumor cell growth in vivo.

HY-170421

MAT2A-IN-16	Inhibitor
MAT2A-IN-16 is a MAT2A inhibitor and inhibits cell proliferation of MTAP^-/- HCT-116 cells (IC₅₀: 20 nM).

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