2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Nuclear Hormone Receptor 4A/NR4A
  5. Nur77/NR4A1 Isoform
  6. Nur77/NR4A1 Agonist

Nur77/NR4A1 Agonist

Nur77/NR4A1 Agonists (3):

Cat. No. Product Name Effect Purity
  • HY-N2148
    Cytosporone B
    		Agonist 98.63%
    Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM.
  • HY-111492
    DIM-C-pPhOCH3
    		Agonist 99.49%
    DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.
  • HY-113827
    THPN
    		Agonist 98.00%
    THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma.