2. Signaling Pathways
  3. Neuronal Signaling
  4. OGA
  5. OGA Inhibitor

OGA Inhibitor

OGA Inhibitors (9):

Cat. No. Product Name Effect Purity
  • HY-12588
    Thiamet G
    		Inhibitor 99.99%
    Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA), which acts to remove O-GlcNAc from modified proteins, with Ki of 20 nM for human OGA.
  • HY-144681
    LY3372689
    		Inhibitor 98.74%
    LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. LY3372689 can be used for tauopathies research, including Alzheimer’s disease.
  • HY-156586
    ASN90
    		Inhibitor 99.63%
    ASN90 is a specific and orally active O-GlcNAcase (OGA) enzyme inhibitor with IC50 value of 10.2 nM. ASN90 can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies.
  • HY-108032
    Hydroxyectoin
    		Inhibitor
    Hydroxyectoin (Pyrostatin A) is a competitive inhibitor of GlcNAcase, with the Ki of 1.7 μM.
  • HY-161953
    O-GlcNAcase-IN-2
    		Inhibitor
    O-GlcNAcase-IN-2 (compound 81) is an orally effective, blood-brain barrier-permeable OGA inhibitor (IC50=4.93 nM). O-GlcNAcase-IN-2 can increase the O-GlcNAcylation level of proteins and phosphorylation of tau (p-Ser199, p-Thr205 and p-Ser396) in the OA-damaged SH-SY5Y cell model. O-GlcNAcase-IN-2 can also improve cognitive impairment in APP/PS1 mice and has potential anti-Alzheimer's disease (AD) effects.
  • HY-139431
    NAG-thiazoline
    		Inhibitor 98.08%
    NAG-thiazoline is a O-GlcNAcase inhibitor with a Ki of 180 nM. NAG-thiazoline is a potent GH20 GlcNAcase (VhGlcNAcase) inhibitor with an IC50 of 11.9 μM and a Ki of 62 µM.
  • HY-148240
    JNJ-65355394
    		Inhibitor
    JNJ-65355394 (Compound 28) is an O-GlcNAc hydrolase (OGA) inhibitor.
  • HY-144681A
    rel-LY3372689
    		Inhibitor
    rel-LY3372689 is a O-GlcNAcase (OGA) inhibitor that can be used to study the neurodegenerative diseases and disorders, such as Alzheimer's disease (WO2018140299A1; Compound Formula Ic).
  • HY-108246
    GlcNAcstatin
    		Inhibitor
    GlcNAcstatin is a selective glucoimidazole-based bacterial O-GlcNAcase inhibitor with a Ki of 4.6 pM. GlcNAcstatin shows 100000-fold selectivity over HexA/B.