Phosphorylase

Phosphorylase is an enzyme that catalyzes the addition of a phosphate group from an inorganic phosphate (phosphate+hydrogen) to an acceptor, including glycogen phosphorylase, starch phosphorylase, nucleoside diphosphate kinase, etc. Phosphorylase participates in cell signal transduction and activates signal pathways through phosphorylation. Phosphorylase plays a crucial role in metabolic processes and is extensively involved in the metabolic regulation of substances such as sugars, nucleotides, and lipids. Phosphorylase can also regulate cell differentiation, proliferation, apoptosis, and gene expression, affecting the fate and function of cells. Abnormal activity or expression of phosphorylase leads to metabolic diseases such as glycogen storage disease, and is also closely related to the occurrence and development of cancer, neurodegenerative diseases, etc^[1].

References:

[1]. Watson KA, et al. Phosphorylase recognition and phosphorolysis of its oligosaccharide substrate: answers to a long outstanding question. EMBO J. 1999 Sep 1;18(17):4619-32. [Content Brief]

Phosphorylase Related Products (13):

By Effects:	Inhibitors (10) Activators (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-108615

CP-316819	Inhibitor	≥99.0%
CP 316819 is a potent glycogen phosphorylase (GPase) inhibitor with antihyperglycemic effect (IC₅₀ values are 17 and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa) respectively).CP 316819 causes glycogen accumulation under normoglycemic conditions but permits glycogen utilization when glucose concentrations are low.CP-316819 prevents neuronal cell death and maintains brain electrical currents.

HY-111926

N6-Methyladenosine 5'-monophosphate disodium salt	Activator	99.74%
N6-Methyladenosine 5'-monophosphate disodium salt is an activator of glycogen phosphorylase b, with a K_a value of 22 µM. N6-Methyladenosine 5'-monophosphate disodium salt is a non-competitive rat adenylate kinase II inhibitor.

HY-19396

Ingliforib	Inhibitor	99.07%
Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC₅₀s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.

HY-W017441A

hUP1-IN-1 potassium	Inhibitor	99.54%
hUP1-IN-1 potassium (compound 6a) is a hUP1 inhibitor with K_ii and K_is Urd of 375 and 635 nM. hUP1-IN-1 potassium showes inhibitory activities over hUP1 catalyzed reaction with 70% at 1 μM. hUP1-IN-1 potassium can be used for the research of cancer.

HY-127018

Maltoheptaose	Activator	99.74%
Maltoheptaose is an activator of phosphorylase B to prepare heptulose-2-phosphate. Maltoheptaose is a maltooligosaccharide contanins seven glucose units.

HY-139140

BAY R3401	Inhibitor
BAY R3401 is an orally active glycogen phosphorylase inhibitor that can achieve irreversible and non-selective inhibition of hepatic glycogenolysis. BAY R3401 inhibits glycogenolysis in liver cells, with IC₅₀ values of 27.06 and 52.83 μM in HL-7702 and HepG2 cells, respectively. BAY R3401 can be used for the research of type 2 diabetes.

HY-W552525

Deoxyadenosine diphosphate sodium	Inhibitor
Deoxyadenosine diphosphate sodium is a nucleoside diphosphate, in which the nucleoside is deoxyadenosine. Deoxyadenosine diphosphate sodium participates in DNA synthesis and repair. Deoxyadenosine diphosphate sodium acts as the inhibitor of polynucleotide phosphorylase, interfers with the polymerization of ADP and CDP.

HY-100320

AVE5688	Inhibitor	98.79%
AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC₅₀s of 430 nM and 915 nM and K_ds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

HY-117172

CP320626	Inhibitor
CP320626 is a potent inhibitor of human liver glycogen phosphorylase (IC₅₀=205 nM). CP320626 reduces blood glucose in diabetic mice without changing plasma insulin levels. CP320626 can be used in the study of type 2 diabetes.

HY-P2735

Phosphorylase b
Phosphorylase b is one of the two forms of phosphorylase present in skeletal muscle. The other is Phosphorylase a, which can be transformed into one another. The conversion process requires the addition of divalent metal ions and ATP.

HY-128029

Glycogen phosphorylase-IN-1	Inhibitor
Glycogen phosphorylase-IN-1 (Compound 42) is an inhibitor for human liver glycogen phosphorylase (hlGPa) and hepatocyte glycogen-derived glucose production with IC₅₀s of 53 and 380 nM, respectively. Glycogen phosphorylase-IN-1 reveals efficacy towards type 2 diabetes.

HY-127018A

Maltoheptaose hydrate	Inhibitor
Maltoheptaose hydrate is an activator of phosphorylase B to prepare heptulose-2-phosphate. Maltoheptaose hydrate is a maltooligosaccharide contanins seven glucose units.

HY-108614

GPi688	Inhibitor
GPi688 is a potent and orally active glycogen phosphorylase (GPa) inhibitor with IC₅₀s of 19 nM, 61 nM and 12 nM for human liver GPa, rat liver GPa and human skeletal muscle GPa, respectively. GPi688 can inhibit glucagons-mediated glucose output in rat primary hepatocytes. GPi688 can be used for researching glucagon-mediated hyperglycaemia.

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