PI4P5K

Phosphatidylinositol 4-phosphate 5-kinases

Phosphatidylinositol 4-phosphate 5-kinases (PI4P5K) are a class of enzymes that phosphorylate phosphatidylinositol 4-phosphate. Phosphatidylinositol 4-phosphate 5-kinases phosphorylate phosphatidylinositol 4-phosphate (PI4P) in the 5-position to form phosphatidylinositol 4,5-bisphosphate (PI45P2). There are two types of phosphatidylinositol 4-phosphate 5-kinases found which includes Type I and Type II. Murine PI4P5K type Ibeta (mPIP5K-Ibeta) was implicated in receptor mediated endocytosis through the isolation of a truncated and inactive form of the enzyme that blocked the ligand-dependent downregulation of the colony-stimulating factor-1 receptor. Phosphatidylinositol 4-phosphate 5-kinases regulate diverse cellular processes such as G protein-coupled receptor(GPCR) signaling, vesicle trafficking, chemotaxis and cellular movement^[1]^[2].

References:

[1]. Jones DH, et al. Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment. J Biol Chem. 2000 May 5;275(18):13962-6. [Content Brief]

[2]. Galiano FJ, et al. Overexpression of murine phosphatidylinositol 4-phosphate 5-kinase type Ibeta disrupts a phosphatidylinositol 4,5 bisphosphate regulated endosomal pathway. J Cell Biochem. 2002;85(1):131-45. [Content Brief]

PI4P5K Inhibitor (1)

PI4P5K Related Products (1):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-16937

ISA-2011B	Inhibitor	99.85%
ISA-2011B is a PIP5K1α inhibitor with promising anticancer effects .

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