2. Signaling Pathways
  3. PI3K/Akt/mTOR
  4. PIN1
  5. PIN1 Degrader

PIN1 Degrader

PIN1 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-164895
    PIN1 degrader-1
    		Degrader
    PIN1 degrader-1 (Compound 158H9) is the inhibitor for proline cis trans isomerase (Pin1) with an IC50 of 21.5 nM. PIN1 degrader-1 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation. PIN1 degrader-1 inhibits the cell viability of multi cancer cells, and can be used in cancer research.