1. Signaling Pathways
  2. Immunology/Inflammation
  3. Programmed Cell Death 4 (PDCD4)

Programmed Cell Death 4 (PDCD4)

Programmed Cell Death 4

Programmed Cell Death 4 (PDCD4) is a critical tumor suppressor protein that plays a pivotal role in regulating apoptosis, cell proliferation, and immune responses by modulating gene translation and transcription. PDCD4 primarily exerts its function by binding to eukaryotic initiation factor 4A (eIF4A), inhibiting its helicase activity and preventing the translation of oncogenic mRNAs with complex 5' UTRs, such as cyclin D1 and c-myc[1]. Additionally, PDCD4 suppresses the transcriptional activity of AP-1 and NF-κB, further contributing to its anti-tumor effects[2]. Downregulation or loss of PDCD4 has been observed in various cancers, including hepatocellular carcinoma, lung cancer, and breast cancer, where it correlates with tumor progression, metastasis, and poor prognosis[3]. Due to its tumor-suppressive functions, PDCD4 has emerged as a potential therapeutic target.

Programmed Cell Death 4 (PDCD4) Related Products (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139682A
    Dovitinib-RIBOTAC TFA
    98.97%
    Dovitinib RIBOTAC TFA is an RNA-targeting RIBOTAC degrader that can specifically bind to and degrade pre-miR-21. Dovitinib RIBOTAC TFA can inhibit the metastasis of breast cancer and has anti-tumor activity.
    Dovitinib-RIBOTAC TFA
  • HY-139682
    Dovitinib-RIBOTAC
    98.93%
    Dovitinib RIBOTAC is an RNA-targeting RIBOTAC degrader that can specifically bind to and degrade pre-miR-21. Dovitinib RIBOTAC can inhibit the metastasis of breast cancer and has anti-tumor activity.
    Dovitinib-RIBOTAC