1. Signaling Pathways
  2. Immunology/Inflammation
  3. Programmed Cell Death 4 (PDCD4)

Programmed Cell Death 4 (PDCD4)

Programmed Cell Death 4

Programmed Cell Death 4 (PDCD4) is a critical tumor suppressor protein that plays a pivotal role in regulating apoptosis, cell proliferation, and immune responses by modulating gene translation and transcription. PDCD4 primarily exerts its function by binding to eukaryotic initiation factor 4A (eIF4A), inhibiting its helicase activity and preventing the translation of oncogenic mRNAs with complex 5' UTRs, such as cyclin D1 and c-myc[1]. Additionally, PDCD4 suppresses the transcriptional activity of AP-1 and NF-κB, further contributing to its anti-tumor effects[2]. Downregulation or loss of PDCD4 has been observed in various cancers, including hepatocellular carcinoma, lung cancer, and breast cancer, where it correlates with tumor progression, metastasis, and poor prognosis[3]. Due to its tumor-suppressive functions, PDCD4 has emerged as a potential therapeutic target.

Programmed Cell Death 4 (PDCD4) Related Products (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P991113
    Abazistobart
    Ligand
    Abazistobart is an immunostimulant and antineoplastic agent targeting the programmed cell death protein 1 (PDCD1). Abazistobart is a chimeric and humanized monoclonal antibody that specifically binds to PDCD1 to block the relevant signaling pathway, thereby activating the immune system and exerting antineoplastic activity. Abazistobart is promising for research of cancers.
    Abazistobart